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Mouse Anti-Human Vascular Endothelial Cell Growth Factor monoclonal antibody  |
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Note: | This product has been discontinued!
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| Full Name | | | Alias | mAHuVEGF |
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| Abbreviated Name-2 | Vascular Endothelial Cell Growth Factor |
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| Description | Vascular endothelial growth factor is an important signaling protein involved in both vasculogenesis and angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells).VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.
Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. |
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| Ig Subclass | Mouse IgM |
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| Storage | The antibody may be stored for long periods in lyophilized form at 4°C in a dry environment. After reconstitution, aliquot and store any antibody not intended for use within one month at -20°C. |
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| Stability | The antibody will remain stable for two years if stored lyophilized, and for one month if stored in solution at 4°C. |
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| Concentration | 1 mg/ml in PBS (after reconstitution) |
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| Clone | A00058.01 |
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| Immunogen | r.HumanVEGF |
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| Purification Method | Boric acid precipitation |
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| Reconstitution | Reconstitute with sterile H2O. Mix gently, wash the sides of the vial, and wait 30-60 seconds before use. |
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| Titer | By direct ELISA, 1:10,000 dilution will yield 0.15 OD using alkaline phosphatase conjugated Rabbit Anti-Mouse Ig (Jackson Laboratories). |
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| Applications | ELISA
Western blot
Immunoprecipitation |
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| Conjugation | Unconjugated |
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| Host Species | Mouse |
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| Antigen Species | Human |
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| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
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| * For Non-Clinical Research Use Only *
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