| |
FITC-Rat Anti-Mouse CD11b monoclonal antibody  |
|
|
Note: | This product has been discontinued!
|
| Catalog No. |
Size |
Price |
Figures |
| Full Name | | | Alias | rAmCD4 |
|---|
| Description | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain. |
|---|
| Ig Subclass | Rat IgG2b |
|---|
| Storage | Lyophilized: store at 4°C.
After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |
|---|
| Stability | Two years lyophilized, one month in solution at 4°C. |
|---|
| Concentration | 1 mg/ml in PBS (after reconstitution) |
|---|
| Clone | A00066.01 |
|---|
| Immunogen | Purified mouse LN CD4+ T cells |
|---|
| Purification Method | Ion exchange column |
|---|
| Reconstitution | Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. |
|---|
| Applications | Staining and blocking antibody.
For staining, use 10 µl/106 cells.
This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator |
|---|
| Conjugation | FITC |
|---|
| Host Species | Rat |
|---|
| Antigen Species | Mouse |
|---|
| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
|---|
| Technical Manual | TM0589, TM0590, TM0591, TM0592, TM0593 |
|---|
| * For Non-Clinical Research Use Only *
 |
1 |
Antibody Services: GenScript's custom antibody service guarantees 1:32,000 ELISA titer of final product or two ELISA positive clones with the help of our advanced antigen design tool. |
2 |
Polyclonal
antibody Services: GenScript's custom polyclonal antibody
services start from $250. It comes with a 1:32,000 ELISA titer guarantee, thanks to our advanced
antigen design tool. |
3 |
Custom
Monoclonal Antibody Services: GenScript's custom monoclonal antibody service
guarantees two ELISA positive clones with the help of advanced hybridoma technology & experienced
professional. | |
If you cannot find your antibodies on our list, try our Express AntibodyTM Service, and receive high-quality, titer-guaranteed antibodies in only 5-8 weeks. Our customer service is available 24 hours, Monday through Friday. You may contact us any time for assistance. |
