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FITC-Rat Anti-Mouse CD11b monoclonal antibody  |
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Note: | This product has been discontinued!
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| Full Name | | | Alias | rAmCD4 |
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| Description | Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Integrin alpha-m/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. CD-11b is identical with cr-3, the receptor for the ic3b fragment of the third complement component. CD-11b probably recognizes the r-g-d peptide in c3b. Integrin alpha-m/beta-2 is also a receptor for fibrinogen, factor x and icam1. it recognizes p1 and p2 peptides of fibrinogen gamma chain. |
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| Ig Subclass | Rat IgG2b |
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| Storage | Lyophilized: store at 4°C.
After reconstitution, if not intended for use within a month, aliquot and store at -20°C. |
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| Stability | Two years lyophilized, one month in solution at 4°C. |
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| Concentration | 1 mg/ml in PBS (after reconstitution) |
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| Clone | A00066.01 |
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| Immunogen | Purified mouse LN CD4+ T cells |
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| Purification Method | Ion exchange column |
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| Reconstitution | Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. |
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| Applications | Staining and blocking antibody.
For staining, use 10 µl/106 cells.
This antibody will block signaling through the CD11a molecule. Titer for blocking should be determined by the investigator |
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| Conjugation | FITC |
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| Host Species | Rat |
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| Antigen Species | Mouse |
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| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
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| * For Non-Clinical Research Use Only * If you cannot find your antibodies on our list, try our Express AntibodyTM Service, and receive high-quality, titer-guaranteed antibodies in only 5-8 weeks. Our customer service is available 24 hours, Monday through Friday. You may contact us any time for assistance. |
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