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Heparanase 1 (HPA1) Antibody, pAb, Rabbit  |
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Note: | This product has been discontinued!
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| Full Name | | | Alias | Anti Human Heparanase 1 |
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| Abbreviated Name-2 | Anti Heparanase 1 |
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| Description | Heparanase is an endo β-D-glucuronidase, which degrades heparin sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasation of tumor cells and inflammatory leukocytes (1, 2, 3). Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis (4,5). Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and a 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form (1, 6). Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival (7, 8). |
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| Storage | The products may be stored at 4°C for short periods, and in aliquots at -20°C for longer periods. Avoid repeated freeze-thaw cycles. |
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| Specificity | Western blot analysis: The antibody reacts with the 65,000 Da precursor as well as the 50,000 Da and 8,000 Da subunits of human and mouse heparanase.
Immunohistochemistry: The antibody interacts with heparanase in paraffin sections and blood smears. |
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| Concentration | 240 ug /100μL in 20 mM sodium phosphate, 150 mM NaCl, pH7.2, containing 0.001% Thimerosal. |
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| Immunogen | Human Heparanase 1 |
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| Applications | WB: 1:1,000
IHC: 1:100
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| Conjugation | Unconjugated |
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| Host Species | Rabbit |
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| Antigen Species | Human |
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| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
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| Technical Manual | TM0589, TM0590, TM0591, TM0592, TM0593 |
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| * For Non-Clinical Research Use Only *
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Antibody Services: GenScript's custom antibody service guarantees 1:32,000 ELISA titer of final product or two ELISA positive clones with the help of our advanced antigen design tool. |
2 |
Polyclonal
antibody Services: GenScript's custom polyclonal antibody
services start from $250. It comes with a 1:32,000 ELISA titer guarantee, thanks to our advanced
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3 |
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professional. | |
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