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Mouse Anti-SCD1 Monoclonal Antibody  |
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| Catalog No. |
Size |
Price |
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A00093-100 ug
| 100 ug | $ 259.00 | MSDS: 20081019221721 (PDF)
EXAMPLE:
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References:
- Zhang Y, et al. Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule. Am. J. Physiol. Renal. Physiol. May 2006; 290(5): F1065-1073.
- Gutierrez-Juarez R, et al. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest. Jun 2006; 116(6): 1686-1695.
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| Full Name | | Mouse Anti-SCD1 Monoclonal Antibody |
| | Alias | Anti SCD1 (monoclonal) |
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| Abbreviated Name-2 | Anti SCD1 |
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| Description | Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355 aa, rat 358 aa; ≈37,000 Da) is constitutively expressed in adipose tissue and is induced in liver in response to fat-free, high-carbohydrate diet. The SCD-1 expression is higher in female than in male mice. The repression of RNA levels and enzyme activity of hepatic SCD-1 by leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 may be beneficial for the treatment of obesity, hepatic steatosis and other metabolic disorders. |
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| Ig Subclass | Mouse monoclonal IgG2B |
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| Storage | The antibody remains stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. The aliquot will remain stable at 4°C for three months. |
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| Specificity | Reacts with human and mouse proteins |
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| Concentration | 1 mg/ml in PBS, pH 7.4 with 0.05% sodium azide, frozen liquid |
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| Clone | A00093.01 |
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| Immunogen | Full-length recombinant protein |
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| Purification Method | Immunoaffinity purification |
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| Applications | Western blot
ELISA
IP
IHC |
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| Conjugation | Unconjugated |
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| Species Reactivity | Human, mouse |
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| Host Species | Mouse |
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| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
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| * For Non-Clinical Research Use Only * If you cannot find your antibodies on our list, try our Express AntibodyTM Service, and receive high-quality, titer-guaranteed antibodies in only 5-8 weeks. Our customer service is available 24 hours, Monday through Friday. You may contact us any time for assistance. |
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