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Plasminogen Antibody, pAb,Sheep  |
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| Catalog No. |
Size |
Price |
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A00128-100 ug
| 100 ug | $ 132.00 | MSDS: 20081020035345 (PDF)
References:
- Kozmin LD, et al. Anti-plasminogen autoantibodies from plasma of patients with systemic lupus erythematosus having anti-phospholipid antibody syndrome: isolation and some immunochemical properties. Biochemistry (Mosc). Mar 2003; 68(3): 339-345.
- Ehrenreich F, et al. Effect of anti plasminogen monoclonal antibodies on whole blood clot lysis. Haemostasis. 1988; 18 Suppl 1: 99-107.
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| Full Name | | Plasminogen Antibody, pAb,Sheep |
| | Alias | Sheep Anti-Human Plasminogen pAb |
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| Abbreviated Name-2 | Anti Human Plasminogen |
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| Description | Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88,500 Da. The plasma concentration is usually in the range of 70-200 mg/L Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the pre-activation peptide. Plasmin consists of a heavy (A-) chain, which contains 5 kringles, and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism. |
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| Ig Subclass | Sheep Polyclonal |
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| Storage | Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stable at 4°C for 3 months. |
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| Specificity | Specifically binds to human plasminogen |
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| Concentration | PBS, pH 7.4 with 0.05% sodium azide |
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| Immunogen | Plasminogen recombinant protein |
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| Purification Method | Immunoaffinity purification |
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| Applications | Western blot: 1:2,500-1:10,000
ELISA: 1:2,500-1:10,000 |
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| Conjugation | Unconjugated |
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| Species Reactivity | Human |
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| Host Species | Sheep |
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| Antigen Species | Human |
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| Note | Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. |
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| * For Non-Clinical Research Use Only *
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