GenScript Catalog Peptide: VIP, guinea pig (RP10084)

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VIP, guinea pig

Cat. No.

Size

Price

Figures

RP10084-0.5 mg

0.5 mg

$ 80.75

MSDS: 20080626033104 (PDF)

References:

Teng BQ, et al. Identification of a VIP-specific receptor in guinea pig tenia coli. Am. J. Physiol. Gastrointest. Liver Physiol. Sep 2001; 281(3): G718-G725.
Zawilska JB, et al. Receptors for VIP and PACAP in guinea pig cerebral cortex: effects on cyclic AMP synthesis and characterization by 125I-VIP binding. J. Mol. Neurosci. Jan 2005; 25(3): 215-224.
Kokubo A, et al. Restoration by VIP of the carbachol-stimulated Cl- secretion in TTX-treated guinea pig distal colon. Jpn. J. Physiol. Dec 2005; 55(6): 317-324.

Full Name

VIP, guinea pig

Alias

VIP

Sequence
(one-letter code)

HSDALFTDTYTRLRKQMAMKKYLNSVLN-NH₂

Sequence
(three-letter code)

{HIS}{SER}{ASP}{ALA}{LEU}{PHE}{THR}{ASP}{THR}{TYR}
{THR}{ARG}{LEU}{ARG}{LYS}{GLN}{MET}{ALA}{MET}{LYS}
{LYS}{TYR}{LEU}{ASN}{SER}{VAL}{LEU}{ASN}-NH₂

C-Terminal

NH₂

Description

Peptide VIP is a vasodilator, bronchodilator and smooth muscle relaxant. Like PACAP, a closely related peptide, VIP is largely inhibitory in the gastrointestinal tract and its neuroprotective actions are mediated by the release of activity-dependent neurotrophic factors from glial cells. To characterize the effects of VIP on both contraction and relaxation of guinea pig gallbladder (GPGB) muscle, cumulative additions of VIP was performed with strips at basal tone or with strips pre-contracted with cholecystokinin-octapeptid, and VIP had no effect on basal tone.

Formula

C₁₄₇H₂₃₉N₄₃O₄₂S₂

M.W.

3344.9

Purity

> 95%

Storage

-20°C

* For Non-Clinical Research Use Only *

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