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Urocortin, human

Cat. No. Size Price Figures
RP10103-0.5 mg
 		0.5 mg
$ 118.75
COA:  20080229021118  (PDF)
MSDS:  20080626044529  (PDF)


References:
  • Gonzalez-Rey E, et al. Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response. Am. J. Pathol. Jun 2006; 168(6): 1921-1930.
  • Bamberger CM, et al. Expression of Urocortin in the Extravillous Human Trophoblast at the Implantation Site. Placenta. May 2006; [Epub ahead of print].
  • Haeger P, et al. Estrogen receptors alpha and beta differentially regulate the transcriptional activity of the Urocortin gene. J. Neurosci. May 2006; 26(18):4908-4916.
Full Name
Urocortin, human
Alias UCN
Sequence
(one-letter code)		 DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
Sequence
(three-letter code)		{ASP}{ASN}{PRO}{SER}{LEU}{SER}{ILE}{ASP}{LEU}{THR}
{PHE}{HIS}{LEU}{LEU}{ARG}{THR}{LEU}{LEU}{GLU}{LEU}
{ALA}{ARG}{THR}{GLN}{SER}{GLN}{ARG}{GLU}{ARG}{ALA}
{GLU}{GLN}{ASN}{ARG}{ILE}{ILE}{PHE}{ASP}{SER}{VAL}-NH2
C-TerminalNH2
DescriptionUrocortin (UCN) is a 40 amino acid peptide that is closely related to corticotropin-releasing hormone. It binds with high affinity to both CRH type 1 and type 2 receptors, and it is expressed in human reproductive tissues including those of the endometrium, ovary, and placenta. UCN stimulates cAMP accumulation from cells transfected with these receptors and acts in vitro to release ACTH from rat anterior pituitary cells.
SolubilityThe peptide is insoluble in water. Dissolve peptide in small amount of 60% acetonitrile with 0.1% TFA solution - followed by water or a buffer.
FormulaC204H337N63O64
M.W.4696.24
Cas176591-49-4
Purity> 95%
StorageStore the peptide at -20°C. Keep container tightly closed.
* For Non-Clinical Research Use Only *
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GN025876 ORF Clone : UCN10 ug
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