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Urocortin, rat

Cat. No. Size Price Figures
RP10104-0.5 mg
0.5 mg
$ 109.25
HPLC:  20060721145613  (PDF)
MS:  20060721145553  (PDF)
DATASHEET:  20080130203946  (DOC)
MSDS:  20080626045449  (PDF)


References:
  • Brar BK, et al. Urocortin increases the expression of heat shock protein 90 in rat cardiac myocytes in a MEK1/2-dependent manner. J. Endocrinol. Feb 2002; 172(2): 283-293.
  • Gordon JM, et al. Cardioprotective action of CRF peptide urocortin against simulated ischemia in adult rat cardiomyocytes. Am. J. Physiol. Heart Circ. Physiol. Jan 2003; 284(1): H330-H336.
  • Wu Y, et al. Expression of urocortin in rat lung and its effect on pulmonary vascular permeability. J. Endocrinol. Apr 2006; 189(1): 167-178.
Full Name
Urocortin, rat
Sequence
(one-letter code)
DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2
Sequence
(three-letter code)
{ASP}{ASP}{PRO}{PRO}{LEU}{SER}{ILE}{ASP}{LEU}{THR}
{PHE}{HIS}{LEU}{LEU}{ARG}{THR}{LEU}{LEU}{GLU}{LEU}
{ALA}{ARG}{THR}{GLN}{SER}{GLN}{ARG}{GLU}{ARG}{ALA}
{GLU}{GLN}{ASN}{ARG}{ILE}{ILE}{PHE}{ASP}{SER}{VAL}-NH2
C-TerminalNH2
DescriptionUrocortin, rat shares ≈95% sequence with its human counterpart and seem to be more potent than CRF at binding and activating type-2 CRF receptors. Urocortin also acts in vitro to release ACTH from rat anterior pituitary cells. Urocortin rat binds to CRF receptor types 1, 2α and 2β stimulates cAMP accumulation from cells transfected with these receptors.
SolubilityThe peptide is insoluble in water. Reconstitute peptide in 25 ml of DMSO. Vortex the mixture thoroughly until the solution is completely clear. Follow this procedure with any desired buffer. Urocortin is a very hydrophobic peptide.
FormulaC206H338N62O64
M.W.4707.26
Cas171543-83-2
Purity> 95%
StorageStore the peptide at -20°C. Keep container tightly closed.
* For Non-Clinical Research Use Only *
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