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Prepro Thyrotropin-Releasing Hormone (TRH) (160-169)

Cat. No. Size Price Figures
RP10108-1 mg
1 mg
$ 43.00
HPLC:  20060721145613  (PDF)
MS:  20060721145553  (PDF)
MSDS:  20080924222622  (PDF)


References:
  • Pekary AE. Is Ps4 (prepro-TRH [160-169]) more than an enhancer for thyrotropin-releasing hormone? Thyroid. Oct 1998; 8(10): 963-968.
  • Pekary AE, et al. Electroconvulsive seizures increase levels of PS4, the TRH-enhancing peptide [prepro-TRH(160-169)], in rat brain. Neuroendocrinology. May 1997; 65(5): 377-384.
Full Name
Prepro Thyrotropin-Releasing Hormone (TRH) (160-169)
Alias Ps4
Sequence
(one-letter code)
SFPWMESDVT
Sequence
(three-letter code)
{SER}{PHE}{PRO}{TRP}{MET}{GLU}{SER}{ASP}{VAL}{THR}
DescriptionThe precursor peptide of TRH (prepro-TRH) contains five copes of pro-TRH linked by other peptide sequences. In a heterologous TSH expression assay, we found that prepro-TRH- (160-169) stimulated TSH beta gene promoter activity in a time- and dose-dependent manner; moreover, the effect of prepro-TRH-(160-169) was more rapid and of greater magnitude than that of TRH on TSH beta- directed chloramphenicol acetyltransferase synthesis. In the same cells, we found that prepro-TRH-(160-169) stimulated PRL synthesis and secretion, but the effect was similar in magnitude and duration to that of TRH. The effect of prepro-TRH-(160-169) appears to be additive to that of TRH, suggesting that prepro-TRH-(160-169) may act through a mechanism separate from that of TRH. Thus, prepro-TRH-(160-169) has potent endocritic effects at the level of the genome.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC54H75N11O18S1
M.W.1198.3
Purity> 95%
StorageBefore using, store the peptide in the DRY form at 0 - 5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.
* For Non-Clinical Research Use Only *
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