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Prepro Thyrotropin-Releasing Hormone (TRH) (160-169)  |
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| Cat. No. |
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RP10108-1 mg
| 1 mg | $ 43.00 | HPLC: 20060721145613 (PDF)
MS: 20060721145553 (PDF)
MSDS: 20080924222622 (PDF)
References:
- Pekary AE. Is Ps4 (prepro-TRH [160-169]) more than an enhancer for thyrotropin-releasing hormone? Thyroid. Oct 1998; 8(10): 963-968.
- Pekary AE, et al. Electroconvulsive seizures increase levels of PS4, the TRH-enhancing peptide [prepro-TRH(160-169)], in rat brain. Neuroendocrinology. May 1997; 65(5): 377-384.
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| Full Name | | Prepro Thyrotropin-Releasing Hormone (TRH) (160-169) |
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| Alias |
Ps4 |
Sequence
(one-letter code) |
SFPWMESDVT | Sequence
(three-letter code) | {SER}{PHE}{PRO}{TRP}{MET}{GLU}{SER}{ASP}{VAL}{THR} |
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| Description | The precursor peptide of TRH (prepro-TRH) contains five copes of pro-TRH linked by other peptide sequences. In a heterologous TSH expression assay, we found that prepro-TRH- (160-169) stimulated TSH beta gene promoter activity in a time- and dose-dependent manner; moreover, the effect of prepro-TRH-(160-169) was more rapid and of greater magnitude than that of TRH on TSH beta- directed chloramphenicol acetyltransferase synthesis. In the same cells, we found that prepro-TRH-(160-169) stimulated PRL synthesis and secretion, but the effect was similar in magnitude and duration to that of TRH. The effect of prepro-TRH-(160-169) appears to be additive to that of TRH, suggesting that prepro-TRH-(160-169) may act through a mechanism separate from that of TRH. Thus, prepro-TRH-(160-169) has potent endocritic effects at the level of the genome. |
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| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
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| Formula | C54H75N11O18S1 |
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| M.W. | 1198.3 |
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| Purity | > 95% |
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| Storage | Before using, store the peptide in the DRY form at 0 - 5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions. |
| * For Non-Clinical Research Use Only *
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