GenScript Catalog Peptide: Prepro Thyrotropin-Releasing Hormone (TRH) (178-199) (RP10109)

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Prepro Thyrotropin-Releasing Hormone (TRH) (178-199)

Cat. No.

Size

Price

Figures

RP10109-1 mg

1 mg

$ 100.00

HPLC:  20060721145613  (PDF)
MS:  20060721145553  (PDF)
MSDS:  20080924225344  (PDF)

References:

Suzuke S, et al. Prepro-thyrotropin releasing hormone 178-199 immunoreactivity is altered in the hypothalamus of the Wistar-Kyoto strain of rat. Brain Res. Sep 2001; 913(2): 224-233.
Borlongan CV, et al. Prepro-thyrotropin-releasing hormone 178-199 exerts partial protection against cerebral ischemia in adult rats. Neuroreport. Nov 1999; 10(17): 3501-3505.

Full Name

Prepro Thyrotropin-Releasing Hormone (TRH) (178-199)

Alias

TRH (178-199)

Sequence
(one-letter code)

FIDPELQRSWEEKEGEGVLMPE

Sequence
(three-letter code)

{PHE}{ILE}{ASP}{PRO}{GLU}{LEU}{GLN}{ARG}{SER}{TRP}
{GLU}{GLU}{LYS}{GLU}{GLY}{GLU}{GLY}{VAL}{LEU}{MET}
{PRO}{GLU}

Description

Prepro-TRH 178-199, a peptide with corticotropin release inhibiting activity at the pituitary, on the Porsolt forced swim test (FST) of depressive behavior in rats. Prepro TRH (178-199) derived from prepro-TRH inhibits basal and CRF-stimulated ACTH synthesis and secretion. Biological activity of this peptide resides in the C-terminal fragment as prepro-TRH 178-199 and prepro-TRH 191-199 were equally potent in the FST. These data suggest that endogenous prepro-TRH 178-199 with its antidepressant-like activity might contribute to the etiology or manifestation of depressive behavior.

Solubility

Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.

Formula

C₁₁₆H₁₇₆N₂₈O₃₉S₁

M.W.

2618.8

Cas

122018-92-2

Purity

> 95%

Storage

Before using, store the peptide in the DRY form at 0 - 5�C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.

* For Non-Clinical Research Use Only *

Precast Gels

Code	Name	Size	Price
RP10108	peptide : Prepro Thyrotropin-Releasing Hormone (TRH) (160-169)	1 mg	$ 43.00
RP10109	peptide : Prepro Thyrotropin-Releasing Hormone (TRH) (178-199)	1 mg	$ 100.00
RP10114	peptide : Thyrotropin-Releasing Hormone (TRH), Free Acid	5 mg	$ 24.00
RP10112	peptide : Thyrotropin-Releasing Hormone (TRH)	5 mg	$ 24.00
GN077387	ORF Clone : Trh	10 ug	$ 960.00
GN074496	ORF Clone : Trh	10 ug	$ 964.00


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