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Substance P  |
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| Cat. No. |
Size |
Price |
Figures |
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RP10178-5 mg
| 5 mg | $ 42.75 | HPLC: 20090204024923 (PDF)
MS: 20090204024952 (PDF)
MSDS: 20070511025917 (PDF)
DATASHEET: 20080130210055 (DOC)
EXAMPLE:
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References:
- Wick EC, et al. Transient receptor potential vanilloid 1, et al. calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. May 2006;290(5):G959-969.
- Allen JW, et al. Safety Evaluation of Intrathecal Substance P-Saporin, a Targeted Neurotoxin, in Dogs. Toxicol Sci. May 2006;91(1):286-298.
- Gontijo JR, et al. CGRP activates renal pelvic substance P receptors by retarding substance P metabolism. Hypertension. Jan 1999;33(1 Pt 2):493-498.
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| Full Name | |
Sequence
(one-letter code) |
RPKPQQFFGLM-NH2 | Sequence
(three-letter code) | {ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}
{MET}-NH2 |
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| C-Terminal | NH2 |
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| Description | Substance P is found in the gut and in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles, and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. It's an NK-1 agonist; a potent vasodilator and hypotensive agent; it induces salivation; it's a putative neurotransmitter in sensory (pain) afferents. |
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| Solubility | Soluble in water (1 mg/ml) |
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| Formula | C63H98N18O13S1 |
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| M.W. | 1347.63 |
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| Cas | 33507-63-0 |
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| Purity | > 95% |
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| Storage | Store the peptide at -20°C. Keep container tightly closed. |
| * For Non-Clinical Research Use Only *
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