Wick EC, et al. Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. Am. J. Physiol. Gastrointest Liver Physiol. May 2006; 290(5): G959-969.
Rohleder N, et al. No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress. Life Sci. May 2006; 78(26): 3082-3089.
Substance P was found in the gut as well as in the brain. It is responsible for a number of excitatory effects on both central and peripheral neurons. Substance P contracts smooth muscle, constricts bronchioles and increases capillary permeability. When released from afferent nerves, Substance P causes a neurogenic inflammatory response, including mast cell degranulation. NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; putative neurotransmitter in sensory (pain) afferents. [Nle11]-Substance P is a Substance P analog that avoids methionine oxidation problems.
Formula
C64H100N18O13
M.W.
1329.59
Cas
57462-42-7
Purity
> 95%
Storage
Store at -20°C. Keep tightly closed. Store in a cool dry place.
* For Non-Clinical Research Use Only *
Our customer service is available 24 hours a day, Monday through Friday. You may contact us any time for assistance.
![[Nle<sup>11</sup>]-Substance P Structure](http://www.genscript.com/site2/document/1391_20060327015118.JPG "[Nle<sup>11</sup>]-Substance P Structure")