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PACAP (6-27), human, ovine, rat

Cat. No. Size Price Figures
RP10337-0.5 mg
 		0.5 mg
$ 81.00
HPLC:  20060721145615  (PDF)
MS:  20060721145555  (PDF)
MSDS:  20080713213617  (PDF)
PROTOCOL:  20100407015038  (PDF)


References:
  • Lamouche S, Yamaguchi N. PACAP release from the canine adrenal gland in vivo: its functional role in severe hypotension. Am. J. Physiol. Regul. Integr. Comp. Physiol. Feb 2003; 284(2): R588-597.
  • Gaspo R, et al. Canine adrenal catecholamine response to VIP is blocked by PACAP-(6-27) in vivo. Am. J. Physiol. May 1997; 272(5Pt2): R1606-1612.
Full Name
PACAP (6-27), human, ovine, rat
Sequence
(one-letter code)		 FTDSYSRYRKQMAVKKYLAAVL-NH2
Sequence
(three-letter code)		{PHE}{THR}{ASP}{SER}{TYR}{SER}{ARG}{TYR}{ARG}{LYS}
{GLN}{MET}{ALA}{VAL}{LYS}{LYS}{TYR}{LEU}{ALA}{ALA}
{VAL}{LEU}-NH2
C-TerminalNH2
DescriptionPACAP (6-27), PACAP-27 inhibitor, is a specific inhibitor of PACAP-27 stimulated adenylate cyclase. It allows a clear functional discrimination between PACAP-27 and PACAP-38 receptors. PACAP-(6-27) diminished, in a dose-dependent manner, the increase in adrenal CA secretion induced by PACAP-27. The results also indicate that the CA response to either PACAP-27 or VIP was selectively inhibited by PACAP-(6-27) but not by VIP-(10-28). It is concluded that PAC1 receptor is primarily involved in the CA secretion induced by both PACAP-27 and VIP in the canine adrenal medulla in vivo.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC121H193N33O31S1
M.W.2638.09
Cas136134-68-4
Purity> 95%
StorageStore at -20°C.
NotesFor PACAP receptor studies. Inhibits PACAP27-stimulated but not PACAP38-stimulated adenylate cyclase activity
* For Non-Clinical Research Use Only *
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RP10338peptide : PACAP (6-38), human, ovine, rat0.5 mg
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RP10339 peptide : PACAP 38, frog0.5 mg
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$ 1026.00
RP10341peptide : PACAP-Related Peptide (PRP), human0.5 mg
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RP10342 peptide : PACAP-Related Peptide (PRP), rat0.5 mg
$ 119.00




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