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Orexin B, canine

Cat. No. Size Price Figures
RP10414-0.5 mg
 		0.5 mg
$ 90.00
MSDS:  20080714013853  (PDF)

EXAMPLE:
orexin B Example
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References:
  • Haj-Dahmane S, Shen RY. The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J. Neurosci. Jan 2005; 25(4): 896-905.
  • Grudt TJ, et al. Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. J. Physiol. Jan 2002; 538(Pt 2):517-525.
Full Name
Orexin B, canine
Sequence
(one-letter code)		 RPGPPGLQGRLQRLLQASGNHAAGILTM-NH2
Sequence
(three-letter code)		{ARG}{PRO}{GLY}{PRO}{PRO}{GLY}{LEU}{GLN}{GLY}{ARG}
{LEU}{GLN}{ARG}{LEU}{LEU}{GLN}{ALA}{SER}{GLY}{ASN}
{HIS}{ALA}{ALA}{GLY}{ILE}{LEU}{THR}{MET}-NH2
C-TerminalNH2
DescriptionThe hypothalamic peptides hypocretin-1 (orexin A) and hypocretin-2 (Hcrt-2; orexin B) are important in modulating behaviours demanding arousal, including sleep and appetite. The wake-promoting neuropeptides orexins (hypocretins) play a crucial role in controlling neuronal excitability and synaptic transmission in the CNS. Orexin B (Orx-B) depresses the evoked glutamate-mediated synaptic currents in DRN 5-HT neurons. The Orx-B-induced depression is accompanied by an increase in the paired-pulse ratio and the coefficient of variance, suggesting a presynaptic site of action. Orx-B also reduces the frequency but not the amplitude of miniature EPSCs, indicating that depression of glutamatergic transmission is mediated by a decrease in glutamate release.
FormulaC125H214N44O34S1
M.W.2909.39
Purity> 95%
StorageStore at -20°C
* For Non-Clinical Research Use Only *
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