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Orexin B, human

Cat. No. Size Price Figures
RP10415-0.5 mg
 		0.5 mg
$ 90.00
HPLC:  20060721145615  (PDF)
MS:  20060721145555  (PDF)
MSDS:  20080714014838  (PDF)

EXAMPLE:
Orexin B, human Example
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References:
  • Lee JH, et al. Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B. J Clin Endocrinol Metab. Oct 2001;86(10): 4818-4821.
  • Haj-Dahmane S, Shen RY. The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J. Neurosci. Jan 2005; 25(4): 896-905.
Full Name
Orexin B, human
Sequence
(one-letter code)		 RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
Sequence
(three-letter code)		{ARG}{SER}{GLY}{PRO}{PRO}{GLY}{LEU}{GLN}{GLY}{ARG}
{LEU}{GLN}{ARG}{LEU}{LEU}{GLN}{ALA}{SER}{GLY}{ASN}
{HIS}{ALA}{ALA}{GLY}{ILE}{LEU}{THR}{MET}-NH2
C-TerminalNH2
DescriptionOrexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons. Orexin B stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC123H212N44O35S1
M.W.2899.34
Purity> 95%
StorageStore at -20°C.
* For Non-Clinical Research Use Only *
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RP10414peptide : Orexin B, canine0.5 mg
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RP10416 peptide : Orexin B, rat, mouse0.5 mg
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