Haj-Dahmane S, Shen RY. The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J. Neurosci. Jan 2005; 25(4): 896-905.
Grudt TJ, et al. Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat. J. Physiol. Jan 2002; 538(Pt2):517-525.
Orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Orexin B activates OX2 receptors. Both OX1 and OX2 receptors are involved in maintaining arousal. OX2 receptors appear to be inhibitory autoreceptors on orexin-containing neurons. Orexin B stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B.
Solubility
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
Formula
C126H215N45O34S
M.W.
2936.4
Purity
> 95%
Storage
Store at -20°C.
* For Non-Clinical Research Use Only *
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