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Kyotorphin  |
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| Cat. No. |
Size |
Price |
Figures |
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RP10428-5 mg
| 5 mg | $ 48.00 | HPLC: 20060721145615 (PDF)
MS: 20060721145555 (PDF)
MSDS: 20080714222229 (PDF)
PROTOCOL: 20100407015038 (PDF)
References:
- Michaelis K, et al. Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain. J.Pharmacol.Exp.Ther. Jun 2006; 317(3): 1246-1253.
- Mizota K, Ueda H. Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells. Toxicol.Sci. Apr 2006; 90(2): 362-368.
- Shen H, et al. PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus. J.Pharmacol.Exp.Ther. Dec 2005; 315(3): 1101-1108.
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| Full Name | |
| Alias |
Kyo, Tyrosine-Arginine |
Sequence
(one-letter code) |
YR | Sequence
(three-letter code) | {TYR}{ARG} |
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| Description | Kyotorphin (Kyo), an endogenous neuropeptide (tyrosine-arginine), plays a role in pain regulation in the brain. This peptide administered centrally produced analgesic effects in mice, possibly through a Met-enkephalin release. The neurochemical basis of mechanisms suggests that Kyo stimulates its specific receptor, followed by Gi and phospholipase C (PLC) activations. Recently, we observed that this PLC mechanism leads to a Ca2+ influx in nerve ending particles or synaptosomes. In this report, we propose the hypothesis that inositol 1,4,5-trisphosphate (InsP3) elicits Ca2+ transport through plasmalemmal InsP3 receptor but not through intrasynaptosomal Ca2+ stores. Because neurochemically dissociated synaptosomes may not be exclusively pure but may contain various other subfractions, however, this hypothesis is required to be further confirmed through more physiological approaches. |
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| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
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| Formula | C15H23N5O4 |
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| M.W. | 337.4 |
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| Cas | 70904-56-2 |
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| Purity | > 95% |
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| Storage | Storage at -20°C. Keep tightly closed. |
| * For Non-Clinical Research Use Only *
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