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Kyotorphin

Cat. No. Size Price Figures
RP10428-5 mg
 		5 mg
$ 47.50
HPLC:  20060721145615  (PDF)
MS:  20060721145555  (PDF)
MSDS:  20080714222229  (PDF)


References:
  • Michaelis K, et al. Covalent linkage of apolipoprotein e to albumin nanoparticles strongly enhances drug transport into the brain. J.Pharmacol.Exp.Ther. Jun 2006; 317(3): 1246-1253.
  • Mizota K, Ueda H. Endocrine disrupting chemical atrazine causes degranulation through Gq/11 protein-coupled neurosteroid receptor in mast cells. Toxicol.Sci. Apr 2006; 90(2): 362-368.
  • Shen H, et al. PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus. J.Pharmacol.Exp.Ther. Dec 2005; 315(3): 1101-1108.
Full Name
Kyotorphin
Alias Kyo, Tyrosine-Arginine
Sequence
(one-letter code)		 YR
Sequence
(three-letter code)		{TYR}{ARG}
DescriptionKyotorphin (Kyo), an endogenous neuropeptide (tyrosine-arginine), plays a role in pain regulation in the brain. This peptide administered centrally produced analgesic effects in mice, possibly through a Met-enkephalin release. The neurochemical basis of mechanisms suggests that Kyo stimulates its specific receptor, followed by Gi and phospholipase C (PLC) activations. Recently, we observed that this PLC mechanism leads to a Ca2+ influx in nerve ending particles or synaptosomes. In this report, we propose the hypothesis that inositol 1,4,5-trisphosphate (InsP3) elicits Ca2+ transport through plasmalemmal InsP3 receptor but not through intrasynaptosomal Ca2+ stores. Because neurochemically dissociated synaptosomes may not be exclusively pure but may contain various other subfractions, however, this hypothesis is required to be further confirmed through more physiological approaches.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC15H23N5O4
M.W.337.4
Cas70904-56-2
Purity> 95%
StorageStorage at -20°C. Keep tightly closed.
* For Non-Clinical Research Use Only *


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