| Cat. No. |
Size |
Price |
Figures |
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RP10468-0.5 mg
| 0.5 mg | $ 23.75 | MSDS: 20080728230016 (PDF)
STRUCTURE:
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References:
- Maggi CA, et al. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J. Pharmacol. Exp. Ther. Jun 1991; 257(3): 1172-1178.
- Quartara L, et al. N-terminal truncated analogs of men 10376 as tachykinin NK-2 receptor antagonists. Life Sci. 1992; 51(25): 1929-1936.
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| Full Name | |
| Alias |
Neurokinin-2 receptor antagonist |
Sequence
(one-letter code) |
DYWVWWK-NH2 | Sequence
(three-letter code) | {ASP}{TYR}{d-TRP}{VAL}{d-TRP}{d-TRP}{LYS}-NH2 |
|---|
| C-Terminal | NH2 |
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| Description | Men 10376 is a potent and selective NK2 tachykinin receptor antagonist. MEN 10376 was devoid of significant agonist activity at i.v. doses (1-3 mumol/kg) which selectively antagonized the effects of an NK-2 agonist [beta-Ala8]-neurokinin A(4-10) (bladder contraction in rats, bronchoconstriction in guinea pigs) without affecting the response to an NK-1 agonist [Sar9]-substance P sulfone (hypotension, salivation and bladder contraction in rats, bronchoconstriction in guinea pigs).
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| Formula | C57H68N12O10 |
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| M.W. | 1081.22 |
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| Cas | 135306-85-3 |
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| Purity | > 95% |
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| Storage | Store at -20°C. Keep tightly closed. |
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