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[Tyr1]-W-MIF-1

Cat. No. Size Price Figures
RP10477-5 mg
 		5 mg
$ 57.00
HPLC:  20060721145617  (PDF)
MS:  20060721145556  (PDF)
MSDS:  20080813213044  (PDF)


References:
  • Watanabe H, et al. A Tyr-W-MIF-1 analog containing D-Pro2 acts as a selective mu2-opioid receptor antagonist in the mouse. J. Pharmacol Exp. Ther. Mar 2005; 312(3): 1075-81.
  • Nachman RJ. Comparison of active conformations of the insectatachykinin/tachykinin and insect kinin/Tyr-W-MIF-1 neuropeptide family pairs. Ann. N. Y. Acad. Sci. 1999; 897: 388-400.
  • Nores WL, et al. Tyr-W-MIF-1-induced conditioned place preference. Peptides. 1999; 20(4): 479-84.
Full Name
[Tyr1]-W-MIF-1
Alias Tyr-W-MIF-1; Tyr-W-MIF1
Sequence
(one-letter code)		 YPWG-NH2
Sequence
(three-letter code)		{TYR}{PRO}{TRP}{GLY}-NH2
C-TerminalNH2
DescriptionA novel tetrapeptide, Tyr-W-MIF-1(Tyr-Pro-Trp-Gly-NH2), was purified from extracts of frontal cortex of human brain tissue by several consecutive reversed-phase high performance liquid chromatographic steps followed by a radioimmunoassay originally developed for Tyr-Pro-Leu-Gly-NH2 (Tyr-MIF-1). Like Tyr-MIF-1, which was previously isolated from human brain tissue, Tyr-W-MIF-1 can inhibit the binding of 3H-DAMGO (selective for mu opiate receptors) to rat brain and can act as an opiate agonist as well as antagonist. Tyr-W-MIF-1 was a more potent opiate agonist than Tyr-MIF-1, the free acid of Tyr-W-MIF-1, and the structurally related hemoglobin-derived opiate peptide hemorphin-4 (Tyr-Pro-Trp-Thr) in the guinea pig ileum. Each of these peptides acted as opiate antagonists on the ileum from morphine-tolerant guinea pigs; the free acid of Tyr-W-MIF-1 was the most potent antagonist in inhibiting the activity of DAMGO. The presence in human brain of a new member of the Tyr-MIF-1 family of biologically active peptides.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC27H32N6O5
M.W.520.58
Cas144450-13-5
Purity> 95%
Storage-20°C
* For Non-Clinical Research Use Only *


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