Moriyama M, et al. The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. Am. J. Physiol Lung Cell Mol. Physiol. May 2006; 290(5): L971-L977.
Moriyama M, et al. The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock. Biochem. Biophys Res. Commun. Mar 2006; 341(4): 1149-1154.
Jethwa PH, et al. Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat. Endocrinology. 2006 Mar.
Neuromedin U is a neuropeptide, first isolated from porcine spinal cord and expressed widely in the gastrointestinal, genitourinary and central nervous systems. Neuromedin U has potent contractile activity on smooth muscle and this activity is believed to reside within the C-terminal portion of the peptide, which is highly conserved between species. Neuromedin U (NMU) is a hypothalamic neuropeptide that regulates body weight and composition. Some studies indicate that NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway. These characteristic functions of NMU may provide new insight for understanding the pathophysiologic basis of obesity.
Solubility
Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
Formula
C124H180N34O31
M.W.
2643
Purity
> 95%
Storage
Store at -20°C
* For Non-Clinical Research Use Only *
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