Cao W, et al. NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon. J. Pharmacol. Exp. Ther. Jun 2006; 317(3): 1349-1355.
Myers AC, et al. A novel role for tachykinin neurokinin-3 receptors in regulation of human bronchial Ganglia neurons. Am. J. Respir. Crit. Care Med. Feb 2005; 171(3): 212-216.
Lynn P, et al. Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut. J. Physiol. Apr 2005; 564(Pt 2): 589-601.
Full Name
Neurokinin A (4-10)
Alias
NKA (4-10)
Sequence (one-letter code)
DSFVGLM-NH2
Sequence (three-letter code)
{ASP}{SER}{PHE}{VAL}{GLY}{LEU}{MET}-NH2
C-Terminal
NH2
Description
A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. Two series of NKA(4-10) analogues were produced with either L-alanine or the D-enantiomer substituted. Their activities were determined in vitro by means of radioligand binding and isolated smooth muscle pharmacology.
Formula
C34H54N8O10S
M.W.
766.9
Cas
97559-35-8
Purity
> 95%
Storage
Store at -20°C.
* For Non-Clinical Research Use Only *
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