GenScript Catalog Peptide: N-Acetyl-Ser-Asp-Lys-Pro (RP10555)

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N-Acetyl-Ser-Asp-Lys-Pro

Cat. No.

Size

Price

Figures

RP10555-5 mg

5 mg

$ 23.75

HPLC: 20060721145617 (PDF)
MS: 20060721145557 (PDF)

STRUCTURE:

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References:

Wdzieczak-Bakala J, et al. Catabolism of the tetrapeptide N-Ac-Ser-Asp-Lys-Pro (AcSDKP), an inhibitor of hematopoietic stem cell (CFU-S) proliferation, following in vitro incubation with hematopoietic tissues from normal and leukemic mice. Bull Cancer. May 1993; 80(5): 391-396.
Wang D, et al. N-acetyl-seryl-aspartyl-lysyl-proline stimulates angiogenesis in vitro and in vivo. Am. J. Physiol Heart Circ. Physiol. Nov 2004; 287(5): H2099-H2105.
Rioli V, et al. Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J. Biol. Chem. Mar 2003; 278(10): 8547-8555.

Full Name

N-Acetyl-Ser-Asp-Lys-Pro

Alias

AcSDKP; Ac-S-D-K-P

Sequence
(one-letter code)

SDKP

Sequence
(three-letter code)

{SER}{ASP}{LYS}{PRO}

Description

Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. Acetyl Ser-Asp-Lys-Pro is also a specific substrate for the N-terminal active site of angiotensin-converting enzyme, which is responsible for its degradation in vivo.

Formula

C₂₀H₃₃N₅O₉

M.W.

487.5

Cas

127103-11-1

Purity

> 95%

Storage

Store at -20°C.

N-Terminal

Notes

(CFU-S = Spleen Colony-Forming Units) N-Acetyl-Ser-Asp-Lys-Pro exerts a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells

* For Non-Clinical Research Use Only *

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