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Thrombin Receptor Agonist

Cat. No. Size Price Figures
RP10623-1 mg
1 mg
$ 61.75
HPLC:  20060721145618  (PDF)
MS:  20060721145558  (PDF)
MSDS:  20080821233606  (PDF)


References:
  • Smith SA, et al. Polyphosphate modulates blood coagulation and fibrinolysis. Proc.Natl.Acad.Sci.USA. Jan 2006; 103(4): 903-908.
  • Suzuki-Inoue K, et al. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood. Jan 2006; 107(2): 542-549.
  • Monroe DM, Hoffman M. What does it take to make the perfect clot. Arterioscler Thromb Vasc Biol. Jan 2006; 26(1): 41-48.
RP10623-5 mg
5 mg
$ 247.00
Full Name
Thrombin Receptor Agonist
Sequence
(one-letter code)
SFLLRNPNDKYEPF
Sequence
(three-letter code)
{SER}{PHE}{LEU}{LEU}{ARG}{ASN}{PRO}{ASN}{ASP}{LYS}
{TYR}{GLU}{PRO}{PHE}
DescriptionA synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for Ca2+ mobilization, and both agonists induced Ca2+ release exclusively from internal stores. Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40,000 Da, 42,000 Da, 70,000 Da, 120,000 Da and 130,000 Da. There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization.
FormulaC81H118N20O23
M.W.1739.9
Cas137339-65-2
Purity> 95%
StorageStore at -20°C.
* For Non-Clinical Research Use Only *
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