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Thrombin Receptor Agonist  |
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| Cat. No. |
Size |
Price |
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RP10623-1 mg
| 1 mg | $ 61.75 | HPLC: 20060721145618 (PDF)
MS: 20060721145558 (PDF)
MSDS: 20080821233606 (PDF)
References:
- Smith SA, et al. Polyphosphate modulates blood coagulation and fibrinolysis. Proc.Natl.Acad.Sci.USA. Jan 2006; 103(4): 903-908.
- Suzuki-Inoue K, et al. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood. Jan 2006; 107(2): 542-549.
- Monroe DM, Hoffman M. What does it take to make the perfect clot. Arterioscler Thromb Vasc Biol. Jan 2006; 26(1): 41-48.
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RP10623-5 mg
| 5 mg | $ 247.00 |
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| Full Name | | Thrombin Receptor Agonist |
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Sequence
(one-letter code) |
SFLLRNPNDKYEPF | Sequence
(three-letter code) | {SER}{PHE}{LEU}{LEU}{ARG}{ASN}{PRO}{ASN}{ASP}{LYS}
{TYR}{GLU}{PRO}{PHE} |
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| Description | A synthetic thrombin receptor agonist peptide (TRP) of 7 residues (SFLLRNP) was found to be as effective as thrombin for Ca2+ mobilization, and both agonists induced Ca2+ release exclusively from internal stores. Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40,000 Da, 42,000 Da, 70,000 Da, 120,000 Da and 130,000 Da. There was a good correlation between thrombin-induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization. |
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| Formula | C81H118N20O23 |
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| M.W. | 1739.9 |
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| Cas | 137339-65-2 |
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| Purity | > 95% |
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| Storage | Store at -20°C. |
| * For Non-Clinical Research Use Only *
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