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Enterostatin (Val-Pro-Asp-Pro-Arg)

Cat. No. Size Price Figures
RP10629-5 mg
 		5 mg
$ 28.50
MSDS:  20080822020530  (PDF)


References:
  • Leibowitz SF, et al. Leptin secretion after a high-fat meal in normal-weight rats: strong predictor of long-term body fat accrual on a high-fat diet. Am. J. Physiol. Endocrinol. Metab. Feb 2006; 290(2): E258-267.
  • Lin L, et al. Different metabolic responses to central and peripheral injection of enterostatin. Am. J. Physiol. Regul. Integr. Comp. Physiol. Apr 2006; 290(4): R909-915.
  • Arsenijevic D, et al. Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin. Am. J. Physiol. Endocrinol. Metab. Jul 2005; 289(1): E40-45.
Full Name
Enterostatin (Val-Pro-Asp-Pro-Arg)
Sequence
(one-letter code)		 VPDPR
Sequence
(three-letter code)		{VAL}{PRO}{ASP}{PRO}{ARG}
DescriptionEnterostatin (VPDPR) is an anorexigenic peptide derived from the amino terminus of procolipase, significantly inhibited analgesia induced by the mu-opioid agonist morphine (5 mg/kg, s.c.) after i.c.v. administration to mice at a dose of 100 nmol. On the other hand, VPDPR (approximately 200 nmol, i.c.v.) did not attenuate analgesia induced by the kappa-opioid agonist D-Phe-D-Phe-D-Nle-D-Arg-NH2 (100 microg/mouse, i.c.v.) or delta-opioid agonist DTLET (4 nmol/mouse, i.c.v.). VPDPR (100 nmol, i.c.v.) significantly improved amnesia induced by scopolamine (0.2 mg/kg, i.p.) in mice. But, VPDPR did not enhance memory in normal mice at the same dose.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC25H42N8O8
M.W.582.7
Cas117137-85-6
Purity> 95%
StorageBefore using, store the peptide in the DRY form at 0 - 5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.
* For Non-Clinical Research Use Only *

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