| Cat. No. |
Size |
Price |
Figures |
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RP10663-0.5 mg
| 0.5 mg | $ 118.75 | MSDS: 20080821033650 (PDF)
References:
- Buku A, et al. Partial alanine scan of mast cell degranulating peptide (MCD): importance of the histidine- and arginine residues. J. Pept. Sci. Jun 2004; 10(6): 313-317.
- Zhang SF, et al. Cloning and characterization analysis of the genes encoding precursor of mast cell degranulating peptide from 2 honeybee and 3 wasp species. Yi Chuan Xue Bao. Sep 2003; 30(9): 861-816.
- Buku A, et al. Histamine-releasing activity and binding to the FcepsilonRI alpha human mast cell receptor subunit of mast cell degranulating peptide analogues with alanine substitutions. J. Med. Chem. Jul 2003; 46(14): 3008-3012.
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| Full Name | | Mast Cell Degranulating Peptide |
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| Alias |
MCDP |
Sequence
(one-letter code) |
IKCNCKRHVIKPHICRKICGKN-NH2 |
Sequence
(three-letter code) | {ILE}{LYS}{CYS}{ASN}{CYS}{LYS}{ARG}{HIS}{VAL}{ILE}
{LYS}{PRO}{HIS}{ILE}{CYS}{ARG}{LYS}{ILE}{CYS}{GLY}
{LYS}{ASN}-NH2(Disulfide bridge: 3-15,5-19) |
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| C-Terminal | NH2 |
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| Chemical Bridge | Disulfide bridge: Cys3-Cys15, Cys5-Cys19 |
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| Description | Mast Cell Degranulating Peptide (MCDP) is a neurotoxic agent isolated from bee venom. It produces a long-term potentiation in the hippocampus. Some studies show that Mast Cell Degranulating Peptide (MCDP) augments the release of excitatory and inhibitory transmitter by an action, which is independent of calcium influx, through voltage-dependent channels. Mast Cell Degranulating Peptide (MCDP) inhibited non-competitively the binding of both radiolabelled dendrotoxin and beta-bungarotoxin but with relatively low potency. |
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| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
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| Formula | C110H192N40O24S4 |
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| M.W. | 2587.22 |
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| Cas | 32908-73-9 |
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| Purity | > 95% |
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| Storage | Before using, store the peptide in the DRY form at 0 - 5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions. |
| Notes | Mast Cell Degranulating Peptide (MCDP) is a very powerful anti-inflammatory peptide, and have potent neurotoxic action. |
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