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Luteinizing Hormone Releasing Hormone (LH-RH), salmon

Cat. No. Size Price Figures
RP10673-1 mg
 		1 mg
$ 23.75
HPLC:  20060721145618  (PDF)
MS:  20060721145558  (PDF)
MSDS:  20080821040447  (PDF)

STRUCTURE:
LH-RH, salmon Structure
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References:
  • Bencini S, et al. Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog. Ann. N. Y. Acad. Sci. Dec 2003; 1010:789-792.
  • Halmos G, Schally AV. Changes in subcellular distribution of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) after treatment with the LH-RH antagonist cetrorelix. Proc. Natl. Acad. Sci. U S A. Jan 2002; 99(2): 961-965.
  • Kovacs M, et al. Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH. Proc. Natl. Acad. Sci. U S A. Feb 2001; 98(4): 1829-1834.
Full Name
Luteinizing Hormone Releasing Hormone (LH-RH), salmon
Alias Luteinizing hormone releasing hormone, salmon
Sequence
(three-letter code)		{pGLU}{HIS}{TRP}{SER}{TYR}{GLY}{TRP}{LEU}{PRO}{GLY}
C-TerminalNH2
DescriptionLH-RH is a hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions. It has been assumed, usually with good reason, that D-amino acids with large aromatic side-chains must be present in position 6 of both LH-RH superagonists and antagonists for the highest levels of biological activity to be reached. However, using one of a recent generation of potent lH-RH inhibitory analogs as a model, we have found that the insertion of D-lysine or, better still, D-arginine in this position results in greater antiovulatory activity in the rat over corresponding D-phenylalanine6- and D-tryptophan6-analogs.
FormulaC60H73N15O13
M.W.1212.31
Cas86073-88-3
Purity> 95%
StorageStore at -20°C.
* For Non-Clinical Research Use Only *
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