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Luteinizing Hormone Releasing Hormone (LH-RH), salmon  |
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Price |
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RP10673-1 mg
| 1 mg | $ 24.00 | HPLC: 20060721145618 (PDF)
MS: 20060721145558 (PDF)
MSDS: 20080821040447 (PDF)
PROTOCOL: 20100407015038 (PDF)
STRUCTURE:
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References:
- Bencini S, et al. Apoptosis in prostate carcinoma before and after neoadjuvant therapy with LH-RH analog. Ann. N. Y. Acad. Sci. Dec 2003; 1010:789-792.
- Halmos G, Schally AV. Changes in subcellular distribution of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) after treatment with the LH-RH antagonist cetrorelix. Proc. Natl. Acad. Sci. U S A. Jan 2002; 99(2): 961-965.
- Kovacs M, et al. Luteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH. Proc. Natl. Acad. Sci. U S A. Feb 2001; 98(4): 1829-1834.
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| Full Name | | Luteinizing Hormone Releasing Hormone (LH-RH), salmon |
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| Alias |
LH-RH, salmon, Luteinizing hormone releasing hormone, salmon |
Sequence
(three-letter code) | {pGLU}{HIS}{TRP}{SER}{TYR}{GLY}{TRP}{LEU}{PRO}{GLY} |
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| C-Terminal | NH2 |
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| Description | LH-RH is a hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions. It has been assumed, usually with good reason, that D-amino acids with large aromatic side-chains must be present in position 6 of both LH-RH superagonists and antagonists for the highest levels of biological activity to be reached. However, using one of a recent generation of potent lH-RH inhibitory analogs as a model, we have found that the insertion of D-lysine or, better still, D-arginine in this position results in greater antiovulatory activity in the rat over corresponding D-phenylalanine6- and D-tryptophan6-analogs. |
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| Formula | C60H73N15O13 |
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| M.W. | 1212.31 |
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| Cas | 86073-88-3 |
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| Purity | > 95% |
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| Storage | Store at -20°C.
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| * For Non-Clinical Research Use Only *
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