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[Gln8]-C517 (LH-RH), chicken

Cat. No. Size Price Figures
RP10689-1 mg
 		1 mg
$ 24.00
HPLC:  20060721145618  (PDF)
MS:  20060721145558  (PDF)
MSDS:  20080821043220  (PDF)
PROTOCOL:  20100407015038  (PDF)

STRUCTURE:
[Gln8] LH-RH, chicken Structure
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References:
  • King JA, et al. Structure of chicken hypothalamic luteinizing hormone-releasing hormone. II. Isolation and characterization. J. Bilo. Chem. Sep 1982; 257(18):10729-10732.
  • Guillemin R, et al. Hypothalamic hormones a.k.a. hypothalamic releasing factors. J. Endocrinol. Jan 2005; 184(1): 11-28.
Full Name
[Gln8]-C517 (LH-RH), chicken
Alias [Gln8]-Luteinizing hormone releasing hormone
Sequence
(three-letter code)		{pGLU}{HIS}{TRP}{SER}{TYR}{GLY}{LEU}{GLN}{PRO}{GLY}
C-TerminalNH2
Description[Gln8] Luteinizing hormone releasing hormone ([Gln8] LH-RH), Avian hypothalamic peptide that stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions. It has been assumed, usually with good reason, that D-amino acids with large aromatic side-chains must be present in position 6 of both LH-RH superagonists and antagonists for the highest levels of biological activity to be reached. However, using one of a recent generation of potent lH-RH inhibitory analogs as a model, we have found that the insertion of D-lysine or, better still, D-arginine in this position results in greater antiovulatory activity in the rat over corresponding D-phenylalanine6- and D-tryptophan6-analogs.
FormulaC54H71N15O14
M.W.1154.23
Cas47922-48-5
Purity> 95%
StorageStore at -20°C.
* For Non-Clinical Research Use Only *
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