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Leptin (116-130), mouse

Cat. No. Size Price Figures
RP10701-0.5 mg
 		0.5 mg
$ 71.25
HPLC:  20060721145618  (PDF)
MS:  20060721145558  (PDF)
MSDS:  20080821221834  (PDF)


References:
  • Grasso P, et al. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes. Nov 1999; 48(11): 2204-2209.
  • Tena-Sempere M, et al. In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat. Eur.J.Endocrinol. Apr 2000; 142(4): 406-410.
  • Grasso P, et al. In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140. Endocrinology. Apr 1997; 138(4): 1413-1418.
Full Name
Leptin (116-130), mouse
Sequence
(one-letter code)		 SCSLPQTSGLQKPES
Sequence
(three-letter code)		{SER}{CYS}{SER}{LEU}{PRO}{GLN}{THR}{SER}{GLY}{LEU}
{GLN}{LYS}{PRO}{GLU}{SER}
DescriptionLeptin is a hormone secreted by adipocytes with an important role in the control of feeding behavior and neuroendocrine function. Leptin stimulates in vivo LH secretion in fasted female rats and in vitro PRL secretion. Recent data indicate that leptin (116-130), an active fragment of the native molecule, exerts effects similar to those of the native peptide on body weight and food intake. The present study was carried out to determine whether this fragment is also able to stimulate LH and PRL secretion.
FormulaC64H108N18O25S1
M.W.1561.72
Purity> 95%
StorageStore at -20°C. Keep tightly closed. Store in a cool dry place.
* For Non-Clinical Research Use Only *
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