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| Galanin Receptor Ligand M35 |
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| Cat. No. |
Size |
Price |
Figures |
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RP10808-0.5 mg
| 0.5 mg | $ 71.25 | HPLC: 20060721145619 (PDF)
MS: 20060721145559 (PDF)
MSDS: 20080703230720 (PDF)
References:
- Kwong SM, et al. Polymorphic Fibril Formation by Residues 10-40 of the Alzheimer's {beta}-Amyloid Peptide. Biophys.J. Jun 2006; 90(12): 4618-4629.
- Kwong SM, et al. Replication Control of Staphylococcal Multiresistance Plasmid pSK41: an Antisense RNA Mediates Dual-Level Regulation of Rep Expression. J.Bacteriol. Jun 2006; 188(12): 4404-4412.
- Tomas A, et al. Regulation of pancreatic {beta}-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway. J.Cell.Sci. May 2006; 119(10): 2156-2167.
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| Full Name | | Galanin Receptor Ligand M35 |
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Sequence
(one-letter code) |
GWTLNSAGYLLGPPPGFSPFR-NH2 | Sequence
(three-letter code) | {GLY}{TRP}{THR}{LEU}{ASN}{SER}{ALA}{GLY}{TYR}{LEU}
{LEU}{GLY}{PRO}{PRO}{PRO}{GLY}{PHE}{SER}{PRO}{PHE}
{ARG}-NH2 |
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| C-Terminal | NH2 |
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| Description | The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic islets. The radiolabelled M35 and performed equilibrium binding studies with [125I] M35 on the rat pancreatic beta-cell line Rin m 5F. Galanin displaces [125I] M35 with the same affinity (KD = 1 nM) as it displaces [125I] galanin. Displacement of [125I] galanin by M35 from Rin m 5F cell membranes shows the presence of two binding sites for M35 with KD-values of 0.3 +/- 0.1 nM and 0.52 +/- 0.03 μM, respectively. |
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| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
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| Formula | C107H153N27O26 |
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| M.W. | 2233.6 |
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| Purity | > 95% |
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| Storage | Store at -20°C |
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