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Phe-Met-Arg-Phe, amide

Cat. No. Size Price Figures
RP10818-10 mg
 		10 mg
$ 48.00
HPLC:  20060721145619  (PDF)
MS:  20060721145559  (PDF)
MSDS:  20080716042359  (PDF)

STRUCTURE:
FMRF-amide Structure
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References:
  • Yamanaka N, et al. Identification of a novel prothoracicostatic hormone and its receptor in the silkworm Bombyx mori.J Biol Chem. Apr 2005; 280(15): 14684-14690.
  • Benveniste RJ, et al. Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor. Development. Dec 1998; 125(23):4757-65.
  • Twan WH, et al. The presence and ancestral role of gonadotropin-releasing hormone in the reproduction of scleractinian coral, Euphyllia ancora. Endocrinology. Jan 2006; 147(1): 397-406.
Full Name
Phe-Met-Arg-Phe, amide
Alias F-M-R-F;-amide; Phe-Met-Arg-Phe amide, Molluscan cardioexcitatory neuropeptide
Sequence
(one-letter code)		 FMRF-NH2
Sequence
(three-letter code)		{PHE}{MET}{ARG}{PHE}-NH2
C-TerminalNH2
DescriptionFMRF-amide belongs to Molluscan Cardioexcitatory Neuropeptide. This peptide appears to localize with neuropeptide Y in some regions of the brain. FMRF-amide inhibits Na+-Ca2+ exchange in cardiac sarcolemma vesicles. The neuropeptide FMRF-amide stimulated enzyme activity 7- to 8-fold (EC50, 1 mM) via receptors that were pharmacologically distinct from those for dopamine and serotonin. FMRF- amide augmented cyclic AMP levels in slices of gill tissue with a time course similar to that for adenylate cyclase activation.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC29H42N8O4S1
M.W.598.76
Cas64190-70-1
Purity> 95%
StorageStore at -20°C
* For Non-Clinical Research Use Only *
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