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Fibronectin CS1 Peptide  |
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| Cat. No. |
Size |
Price |
Figures |
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RP10838-1 mg
| 1 mg | $ 24.00 | MSDS: 20060322032347 (PDF)
HPLC: 20060721145619 (PDF)
MS: 20060721145559 (PDF)
References:
- Masumoto A, Hemler ME. Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J. Biol. Chem. Jan 1993 5; 268(1): 228-234.
- Yokota T, et al. Growth-supporting activities of fibronectin on hematopoietic stem/progenitor cells in vitro and in vivo: structural requirement for fibronectin activities of CS1 and cell-binding domains. Blood. May 1998; 91(9): 3263-3272.
- Masumoto A, Hemler ME. Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J. Cell Biol. Oct 1993; 123(1): 245-253.
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RP10838-5 mg
| 5 mg | $ 62.00 |
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| Full Name | |
| Alias |
CS1 peptide of fibronectin |
Sequence
(one-letter code) |
EILDVPST | Sequence
(three-letter code) | {GLU}{ILE}{LEU}{ASP}{VAL}{PRO}{SER}{THR} |
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| Description | The connecting segment 1 (CS-1) is a cell attachment domain located in the type III homology connecting segment (IIICS) of fibronectin. CS1 peptide of fibronectin, which lacks the Arg-Gly-Asp-containing domain, actively inhibits tumor metastases in spontaneous and experimental metastasis models. The use of Fibronectin CS1 Peptide might offer a promising therapeutic approach for combating and preventing cancer metastasis.
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| Solubility | The peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents. |
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| Formula | C38H64N8O15 |
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| M.W. | 872.96 |
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| Purity | > 95% |
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| Storage | Before use, store the peptide in the DRY form at 0-5°C. For best and most repeatable results, rehydrate the peptide immediately before use. Do not re-freeze any unused portions. | | Notes | This peptide is part of the fibronectin receptor which is identical to the integrin receptor of α4 β1. It completely inhibits lymphocyte adhesion to CS1 and partially inhibits adhesion to intact fibronectin. The 38,000 Da fragment and has no effect on lymphocyte adhesion to an 80,000 Da fragment containing the RCDS adhesion null. |
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| * For Non-Clinical Research Use Only *
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Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $2.56 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
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Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
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Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.
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