Zhou D, et al. Expression, purification, crystallization and preliminary X-ray characterization of the GRP carbohydrate-recognition domain from Homo sapiens. Acta. Crystallograph Sect. F. Struct. Biol. Cryst. Commun. May 2006; 62(Pt 5): 474-476.
Johnson CV, et al. Evaluation of combined (177)Lu-DOTA-8-AOC-BBN (7-14)NH(2) GRP receptor-targeted radiotherapy and chemotherapy in PC-3 human prostate tumor cell xenografted SCID mice. Cancer Biother Radiopharm. Apr 2006; 21(2): 155-166.
Full Name
Gly-Pro-Arg
Alias
GPR; GLY-PRO-ARG
Sequence (one-letter code)
GPR
Sequence (three-letter code)
{GLY}{PRO}{ARG}
Description
The GPR peptide sequence (28 amino acids) encompassed the consensus sequence defined by the four GPR motifs conserved in the family of AGS3 proteins. The GPR consensus peptide effectively prevented the binding of AGS3 to Gialpha1,2 in protein interaction assays, inhibited guanosine 5'-O-(3-thiotriphosphate) binding to Gialpha, and stabilized the GDP-bound conformation of Gialpha. The GPR peptide had little effect on nucleotide binding to Goalpha and brain G-protein indicating selective regulation of Gialpha. Thus, the GPR peptide functions as a guanine nucleotide dissociation inhibitor for Gialpha. The GPR consensus peptide also blocked receptor coupling to Gialphabetagamma indicating that although the AGS3-GPR peptide stabilized the GDP-bound conformation of Gialpha, this conformation of Gialpha(GDP) was not recognized by a G-protein coupled receptor.
Formula
C13H24N6O4
M.W.
328.4
Purity
> 95%
Storage
Store at -20°C. Keep tightly closed. Store in a cool dry place.
* For Non-Clinical Research Use Only *
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