| Cat. No. |
Size |
Price |
Figures |
|---|
RP10847-1 mg
| 1 mg | $ 23.75 | MSDS: 20080924033507 (PDF)
References:
- Sarin V, et al. Arginine-glycine-aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via alpha 5 beta 1 integrin.
J. Physiol. Apr 2005; 564(Pt 2): 603-617.
- Okroj M, et al. In vitro and in vivo analyses of the biological activity of RGD peptides towards Ab Bomirski melanoma. Cell Mol. Biol. Lett. 2003; 8(4): 873-884.
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| Full Name | |
| Alias |
GRGDNP; GLY-ARG-GLY-ASP-ASN-PRO |
Sequence
(one-letter code) |
GRGDNP |
Sequence
(three-letter code) | {GLY}{ARG}{GLY}{ASP}{ASN}{PRO} |
|---|
| Description | G-R-G-D-N-P is a superior inhibitor of cell attachment to fibronectin and a weak inhibitor of cell attacment to vitronectin. It also inhibits binding of fibrinogen, fibronectin, vitronectin and von Willebrand factor to platelets and resists to carboxypeptidases. G-R-G-D-N-P induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. It contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. G-R-G-D-N-P inhibits cell adhesion to fibronectin 80-90% at 1 mM. |
|---|
| Formula | C23H38N10O10 |
|---|
| M.W. | 614.6 |
|---|
| Cas | 114681-65-1 |
|---|
| Purity | > 95% |
|---|
| Storage | Store at -20°C. Keep tightly closed. Store in a cool dry place.
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