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Gly-Arg-Gly-Asp-Asn-Pro

Cat. No. Size Price Figures
RP10847-1 mg
 		1 mg
$ 23.75
MSDS:  20080924033507  (PDF)


References:
  • Sarin V, et al. Arginine-glycine-aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via alpha 5 beta 1 integrin. J. Physiol. Apr 2005; 564(Pt 2): 603-617.
  • Okroj M, et al. In vitro and in vivo analyses of the biological activity of RGD peptides towards Ab Bomirski melanoma. Cell Mol. Biol. Lett. 2003; 8(4): 873-884.
Full Name
Gly-Arg-Gly-Asp-Asn-Pro
Alias GRGDNP; GLY-ARG-GLY-ASP-ASN-PRO
Sequence
(one-letter code)		 GRGDNP
Sequence
(three-letter code)		{GLY}{ARG}{GLY}{ASP}{ASN}{PRO}
DescriptionG-R-G-D-N-P is a superior inhibitor of cell attachment to fibronectin and a weak inhibitor of cell attacment to vitronectin. It also inhibits binding of fibrinogen, fibronectin, vitronectin and von Willebrand factor to platelets and resists to carboxypeptidases. G-R-G-D-N-P induces apoptosis in various cell types and cell lines at 1mM by a mechanism involving cellular uptake and possible direct stimulation of procaspase-3 autoprocessing. It contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. G-R-G-D-N-P inhibits cell adhesion to fibronectin 80-90% at 1 mM.
FormulaC23H38N10O10
M.W.614.6
Cas114681-65-1
Purity> 95%
StorageStore at -20°C. Keep tightly closed. Store in a cool dry place.
* For Non-Clinical Research Use Only *
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