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Arg-Gly-Asp-Ser

Cat. No. Size Price Figures
RP10861-5 mg
 		5 mg
$ 23.75
HPLC:  20050919140131  (PDF)
MASS SPECE:  20050919140153  (PDF)

STRUCTURE:
RGDS Structure
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References:
  • Hou RZ, et al. Alcalase-catalyzed, kinetically controlled synthesis of a precursor dipeptide of RGDS in organic solvents. Prep. Biochem. Biotechnol. 2006; 36(1): 93-105.
  • DeLong SA, et al. Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration. J. Control Release. Dec 2005; 109(1-3): 139-148.
  • Mineur P, et al. RGDS and DGEA-induced [Ca2+]i signalling in human dermal fibroblasts. Biochim. Biophys. Acta. Oct 2005; 1746(1): 28-37.
Full Name
Arg-Gly-Asp-Ser
Alias RGDS
Sequence
(one-letter code)		 RGDS
Sequence
(three-letter code)		{ARG}{GLY}{ASP}{SER}
DescriptionR-G-D-S, Arg-Gly-Asp-Ser, supports fibroblast attachment and inhibits fibronectin binding to platelets. It is the target sequence for syphilis spirochete adherence. RGDS increases ILK activity and the tyrosine phosphorylation of HMC proteins as well. In the case of tyrosine kinases, similar effects have been demonstrated in other cell types whereas the involvement of ILK, a serine-threonine kinase, in RGD effects has been less studied. To test the relevance of these two types of kinases in the stimulation of TGF-ß1 synthesis by RGDS, activities were blocked by pharmacological or transfection means.
SolubilityThis peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
FormulaC15H27N7O8
M.W.433.42
Cas91037-65-9
Purity> 95%
StorageStore the peptide at -20°C. Keep container tightly closed.
NotesExhibits cell attachment promoting activity
* For Non-Clinical Research Use Only *


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