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Dermenkephalin

Cat. No. Size Price Figures
RP10881-1 mg
 		1 mg
$ 23.75
HPLC:  20060721145619  (PDF)
MS:  20060721145559  (PDF)
MSDS:  20080923033610  (PDF)


References:
  • Gastard M. Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation. BMC Neurosci. 2000.
  • Riand J, et al. The delta-selective opioid peptide dermenkephalin and the mu-selective hybrid peptide dermenkephalin-[1-4]-dermophin-[5-7] display strikingly different conformations despite identical tetrapeptide N-termini. A quantitative 2-D NMR and molecular modeling analysis. J. Biomol. Struct. Dyn. Dec 1999; 17(3): 445-460.
  • Naim M, et al. Solution conformations of deltorphin-I obtained from combined use of quantitative 2D-NMR and energy calculations: a comparison with dermenkephalin. J. Pept. Res. Dec 1998; 52(6): 443-456.
RP10881-5 mg
 		5 mg
$ 80.75
Full Name
Dermenkephalin
Sequence
(one-letter code)		 YMFHLMD-NH2
Sequence
(three-letter code)		{TYR}{d-MET}{PHE}{HIS}{LEU}{MET}{ASP}-NH2
C-TerminalNH2
DescriptionDermenkephalin molecules corresponding to the predicted prodermorphin heptapeptide were first isolated from skin extracts of the South American frog Phyllomedusa sauvagei. It acts as a highly potent and fully selective agonist for the delta opioid receptor. Dermenkephalin has no structural features in common with the sequences any of the hitherto known opioid peptides. It should be a useful tool for identifying conformational determinants for high affinity and selective binding of opioids to the delta receptor.
SolubilityDermenkephalin is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out any smaller portion of the contents.
FormulaC44H62N10O10S2
M.W.955.3
Purity> 95%
StorageBefore using, store dermenkephalinthe in the DRY form at 0-5°C. For best and most repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.
NotesDermenkephalin shows high selectivity and affinity for dopiod receptors.
* For Non-Clinical Research Use Only *


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