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Endomorphin-1

Cat. No. Size Price Figures
RP10925-5 mg
 		5 mg
$ 43.00
HPLC:  20060721145620  (PDF)
MS:  20060721145559  (PDF)

STRUCTURE:
Endomorphin-1 Structure
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References:
  • Botros M, et al. Endomorphin-1 and endomorphin-2 differentially interact with specific binding sites for substance P (SP) aminoterminal SP(1-7) in the rat spinal cord.. Peptides. Apr 2006; 27(4): 753-739.
  • Okutsu H, et al. Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively. Neuropsychopharmacology. Feb 2006; 31(2): 375-383.
  • Leng DN, et al. Endomorphin-1 is more potent than endomorphin-2 in inhibition of synaptic transmission in substantia gelatinosa of adult rat spinal cord. Int. J. Neurosci. Nov 2005; 115(11): 1515-1526.
Full Name
Endomorphin-1
Alias Endomorphin1; EM-1; EM1
Sequence
(one-letter code)		 YPWF-NH2
Sequence
(three-letter code)		{TYR}{PRO}{TRP}{PHE}-NH2
C-TerminalNH2
DescriptionEndomorphin-1 (EM-1) is a recently isolated endogenous peptide having potent analgesic activity and high affinity and selectivity for the mu-opioid receptor. Endomorphin-1 activates G proteins and inhibits adenylyl cyclase activity in membrane preparations from cells stably expressing the mu opioid receptor, an effect reversed by the mu receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2). However, endomorphin-1 appears to have no influence on cells stably expressing the delta opioid receptor.
SolubilityThe peptide is soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
FormulaC34H38N6O5
M.W.610.7
Cas189388-22-5
Purity> 95%
StorageStore the peptide at -20°C. Keep container tightly closed.
NotesEndomorphin-1 is a potent, selective endogenous μ opioid receptor agonist.
* For Non-Clinical Research Use Only *
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RP10926peptide : Endomorphin-25 mg
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