| Cat. No. |
Size |
Price |
Figures |
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RP11002-0.5 mg
| 0.5 mg | $ 61.75 | MSDS: 20080922224446 (PDF)
STRUCTURE:
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References:
- Kato M, et al. SK Channel Blocker Apamin Inhibits Slow Afterhyperpolarization Currents in Rat Gonadotropin-Releasing Hormone Neurones. J. Physiol. 2006 Apr.
- Deschaux O, Bizot JC. Apamin produces selective improvements of learning in rats. Neurosci. Lett. Sep 2005; 386(1): 5-8.
- Mpari B, et al. Differential effects of two blockers of small conductance Ca2+-activated K+ channels, apamin and lei-Dab7, on learning and memory in rats. J. Integr. Neurosci. Sep 2005; 4(3): 381-396.
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| Full Name | |
Sequence
(one-letter code) |
CNCKAPETALCARRCQQH-NH2 |
Sequence
(three-letter code) | {CYS}{ASN}{CYS}{LYS}{ALA}{PRO}{GLU}{THR}{ALA}{LEU}
{CYS}{ALA}{ARG}{ARG}{CYS}{GLN}{GLN}{HIS}-NH2 |
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| C-Terminal | NH2 |
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| Chemical Bridge | Disulfide Bridge Cys1-Cys11 and Cys3-Cys15 |
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| Description | Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a highly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs. |
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| Formula | C79H131N31O24S4 |
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| M.W. | 2027.3 |
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| Cas | 24345-16-2 |
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| Purity | > 95% |
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| Storage | Store at -20°C. Keep tightly closed. Store in a cool dry place. |
| Notes | Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker. |
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