GenScript Catalog Peptide: Calcitonin Gene Related Peptide (CGRP) (8-37), human (RP11089)

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Calcitonin Gene Related Peptide (CGRP) (8-37), human

Cat. No.

Size

Price

Figures

RP11089-0.5 mg

0.5 mg

$ 90.25

HPLC:  20081117023516  (PDF)
MS:  20081117023556  (PDF)
MSDS:  20080707013814  (PDF)

References:

Kawase T, et al. Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)(2,7)] calcitonin gene-related peptide and CGRP(8-37). Am. J. Physiol., Cell Physiol. Oct 2005; 289(4): C811-818.
Gangula PR, et al. Infusion of pregnant rats with calcitonin gene-related peptide (CGRP)(8-37), a CGRP receptor antagonist, increases blood pressure and fetal mortality and decreases fetal growth. Biol. Reprod. Aug 2002; 67(2): 624-629.
Chu DQ, et al. The calcitonin gene-related peptide (CGRP) antagonist CGRP(8-37) blocks vasodilatation in inflamed rat skin: involvement of adrenomedullin in addition to CGRP. Neurosci. Lett. Sep 2001; 310(2-3): 169-172.

Full Name

Calcitonin Gene Related Peptide (CGRP) (8-37), human

Alias

α-CGRP 8-37, FBHuman

Sequence
(one-letter code)

VTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH₂

Sequence
(three-letter code)

{VAL}{THR}{HIS}{ARG}{LEU}{ALA}{GLY}{LEU}{LEU}{SER}
{ARG}{SER}{GLY}{GLY}{VAL}{VAL}{LYS}{ASN}{ASN}{PHE}
{VAL}{PRO}{THR}{ASN}{VAL}{GLY}{SER}{LYS}{ALA}{PHE}-NH₂

C-Terminal

NH₂

Description

Calcitonin-Gene-Related Peptide (CGRP) (8-37) inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats. The present study was performed to explore the effect of CGRP (8-37) on the electrical stimulation-evoked discharge frequency of wide dynamic range (WDR) neurons in the dorsal horn of the spinal cord in rats. CGRP (8-37) was applied directly on the dorsal surface of the L3 to L5 spinal cord. The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord.

Solubility

Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.

Formula

C₁₃₉H₂₃₀N₄₄O₃₈

M.W.

3125.59

Cas

119911-68-1

Purity

> 95%

Storage

Store the peptide at -20�C. Keep container tightly closed. Store with desiccant.

Notes

Calcitonin-Gene-Related Peptide (CGRP) (8-37) is a selective antagonist for CGRP receptors and an agonist for calcitonin receptors.

* For Non-Clinical Research Use Only *

Precast Gels

Code	Name	Size	Price
RP11090	peptide : Calcitonin Gene Related Peptide (CGRP) (8-37), rat	0.5 mg	$ 90.25
RP11092	peptide : Calcitonin Gene Related Peptide (CGRP) II, rat	0.5 mg	$ 118.75
RP11093	peptide : Calcitonin Gene Related Peptide (CGRP), chicken	0.5 mg	$ 118.75
RP11095	peptide : Calcitonin Gene Related Peptide (CGRP), rat	0.5 mg	$ 128.25

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