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C-Type Natriuretic Peptide (CNP), chicken

Cat. No. Size Price Figures
RP11112-0.5 mg
 		0.5 mg
$ 80.75
MSDS:  20080814053104  (PDF)


References:
  • Rahmutula D, Gardner DG. C-type natriuretic Peptide down-regulates expression of its cognate receptor in rat aortic smooth muscle cells. Endocrinology. Nov 2005;146(11):4968-74.
  • Soeki T, Kishimoto I et al. C-type natriuretic peptide, a novel antifibrotic and antihypertrophic agent, prevents cardiac remodeling after myocardial infarction. J Am Coll Cardiol. Feb 2005;45(4):608-16.
  • Su J, Zhang Q et al. Functional effects of C-type natriuretic peptide and nitric oxide are attenuated in hypertrophic myocytes from pressure-overloaded mouse hearts. Am J Physiol Heart Circ Physiol. Mar 2005;288(3):H1367-73.
Full Name
C-Type Natriuretic Peptide (CNP), chicken
Sequence
(one-letter code)		 GLSRSCFGVKLDRIGSMSGLGC
Sequence
(three-letter code)		{GLY}{LEU}{SER}{ARG}{SER}{CYS}{PHE}{GLY}{VAL}{LYS}
{LEU}{ASP}{ARG}{ILE}{GLY}{SER}{MET}{SER}{GLY}{LEU}
{GLY}{CYS}
Chemical BridgeDisulfide bridge: Cys6-Cys22
DescriptionC-Type Natriuretic Peptide(CNP) was originally isolated as a 22-amino-acid peptide from the brain. CNP is synthesized and released from cultured endothelial cells. CNP has been found to act as a coronary vasodilator through activation of cGMP by activating a particulate gyanylate cyclase.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
FormulaC93H157N29O29S3
M.W.2241.7
Purity> 95%
StorageBefore using, store the peptide in the DRY form at 0 - 5°C. For best and repeatable results, rehydrate the peptide immediately before using. Do not re-freeze any unused portions.
NotesC-Type Natriuretic Peptide (chicken) shows chick rectum relaxant activity. CNP induces diuretic-natriuretic and hypotensive responses in a manner similar to that of ANP and BNP.
* For Non-Clinical Research Use Only *
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