Xiao D, et al. Bombesin regulates cyclin D1 expression through the early growth response protein Egr-1 in prostate cancer cells. Cancer Res. Nov 2005; 65(21): 9934-9942.
Li L, Wice BM. et al. Bombesin and nutrients independently and additively regulate hormone release from GIP/Ins cells. Am. J. Physiol. Endocrinol. Metab. Jan 2005; 288(1): E208-215.
Zhang H, et al. Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors. Cancer Res. Sep 2004; 64(18): 6707-6715.
Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. Bombesin has two known homologues in mammals called neuromedin B and gastrin releasing peptide. Bombesin works on the gastrointestinal tract neuroendocrine hormone and bombesin stimulates gastrin release from G cells. Bombesin activates three different G-protein coupled receptors known as BBR1 2 and 3. Bombesin also activates these receptors in the brain. Together with cholecystokinin bombesin is the second major source of negative feedback signals that stop eating behavior.
Solubility
20 mg/ml CH3COOH 0.05 M clear, colorless
Formula
C71H110N24O18S1
M.W.
1619.9
Cas
31362-50-2
Purity
> 95%
Storage
Store at -20°C
* For Non-Clinical Research Use Only *
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