Dumesny C, et al. Synthesis, expression and biological activity of the prohormone for gastrin releasing peptide (ProGRP). Endocrinology. Jan 2006; 147(1): 502-509.
Fleischmann A, et al. Gastrin-releasing peptide receptors in normal and neoplastic human uterus: involvement of multiple tissue compartments. J. Clin. Endocrinol. Metab. Aug 2005; 90(8): 4722-4729.
Engel JB, et al. Effective inhibition of experimental human ovarian cancers with a targeted cytotoxic bombesin analogue AN-215. Clin. Cancer Res. Mar 2005; 11(6): 2408-2415.
Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. Bombesin has two known homologues in mammals called neuromedin B and gastrin releasing peptide. Bombesin works on the gastrointestinal tract neuroendocrine hormone and bombesin stimulates gastrin release from G cells. Bombesin activates three different G-protein coupled receptors known as BBR1 2 and 3. Bombesin also activates these receptors in the brain. Together with cholecystokinin bombesin is the second major source of negative feedback signals that stop eating behavior.
Formula
C74H108N24O19S1
M.W.
1669.9
Cas
67338-70-9
Purity
> 95%
Storage
Store at -20°C
* For Non-Clinical Research Use Only *
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