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Dermaseptin

Cat. No. Size Price Figures
RP11228-0.5 mg
0.5 mg
$ 157.00
MSDS:  20080702214540  (PDF)


References:
  • Rydlo T, et al. Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions. Antimicrob. Agents Chemother. Feb 2006; 50(2): 490-497.
  • Shalev DE, et al. Consequences of N-acylation on structure and membrane binding properties of dermaseptin derivative K4-S4-(1-13). J. Biol. Chem. Apr 2006; 281(14): 9432-9438.
  • Balaban N, et al. A chimeric peptide composed of a dermaseptin derivative and an RNA III-inhibiting peptide prevents graft-associated infections by antibiotic-resistant staphylococci. Antimicrob. Agents Chemother. Jul 2004; 48(7): 2544-2550.
Full Name
Dermaseptin
Sequence
(one-letter code)
ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ
Sequence
(three-letter code)
{ALA}{LEU}{TRP}{LYS}{THR}{MET}{LEU}{LYS} {LYS}{LEU}{GLY}
{THR}{MET}{ALA}{LEU}{HIS} {ALA}{GLY}{LYS}{ALA}{ALA}{LEU}
{GLY}{ALA} {ALA}{ALA}{ASP}{THR}{ILE}{SER}{GLN}{GLY} {THR}{GLN}
DescriptionDermaseptins are antimicrobial peptides, strings of amino acids, or proteins, of various sizes and shapes. Dermaseptins were isolated from frog skin. Dermaseptin is a crucial part of the frog's immune system, inhibiting the growth of bacteria, protozoa and fungi. Dermaseptins are cationic (positively charged) and 27-34 residues in length. Dermaseptins adopt a largely K-helical conformation when binding to membranes. Like other antimicrobial peptides, dermaseptin is membrane-perturbing; however, unlike other antimicrobial peptides, dermaseptin rests on the surface of the bacterial membrane and does not insert.
FormulaC152H257N43O44S2
M.W.3455.1
Cas136212-91-4
Purity> 95%
StorageStore at -20°C. Keep tightly closed. Store in a cool dry place.
NotesHighly potent antimicrobial activity against pathogenic fungi.
* For Non-Clinical Research Use Only *


1
Peptide Services: GenScript's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
2
Standard Peptide Synthesis: GenScript offers quality peptides at the most competitive prices in the industry, starting at $2.56 per amino acid. GenScript FlexPeptideTM technology can synthesize peptide as long as 200 amino acids, a world record for such technology.
3
Peptide Modifications: GenScript offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
4
Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.




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