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Dermaseptin  |
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| Cat. No. |
Size |
Price |
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RP11228-0.5 mg
| 0.5 mg | $ 156.75 | MSDS: 20080702214540 (PDF)
References:
- Rydlo T, et al. Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions. Antimicrob. Agents Chemother. Feb 2006; 50(2): 490-497.
- Shalev DE, et al. Consequences of N-acylation on structure and membrane binding properties of dermaseptin derivative K4-S4-(1-13). J. Biol. Chem. Apr 2006; 281(14): 9432-9438.
- Balaban N, et al. A chimeric peptide composed of a dermaseptin derivative and an RNA III-inhibiting peptide prevents graft-associated infections by antibiotic-resistant staphylococci. Antimicrob. Agents Chemother. Jul 2004; 48(7): 2544-2550.
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| Full Name | |
Sequence
(one-letter code) |
ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ | Sequence
(three-letter code) | {ALA}{LEU}{TRP}{LYS}{THR}{MET}{LEU}{LYS}
{LYS}{LEU}{GLY}
{THR}{MET}{ALA}{LEU}{HIS}
{ALA}{GLY}{LYS}{ALA}{ALA}{LEU}
{GLY}{ALA}
{ALA}{ALA}{ASP}{THR}{ILE}{SER}{GLN}{GLY}
{THR}{GLN} |
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| Description | Dermaseptins are antimicrobial peptides, strings of amino acids, or proteins, of various sizes and shapes. Dermaseptins were isolated from frog skin. Dermaseptin is a crucial part of the frog's immune system, inhibiting the growth of bacteria, protozoa and fungi. Dermaseptins are cationic (positively charged) and 27-34 residues in length. Dermaseptins adopt a largely K-helical conformation when binding to membranes. Like other antimicrobial peptides, dermaseptin is membrane-perturbing; however, unlike other antimicrobial peptides, dermaseptin rests on the surface of the bacterial membrane and does not insert. |
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| Formula | C152H257N43O44S2 |
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| M.W. | 3455.1 |
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| Cas | 136212-91-4 |
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| Purity | > 95% |
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| Storage | Store at -20°C. Keep tightly closed. Store in a cool dry place. | | Notes | Highly potent antimicrobial activity against pathogenic fungi. |
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| * For Non-Clinical Research Use Only *
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