GenScript Catalog Peptide: Histatin 5 (RP11240)

Gusman H, et al. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease. Infect Immun. Mar 2001; 69(3): 1402-1408.
Helmerhorst EJ, et al. The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species. Proc Natl Acad Sci U S A. Dec 2001; 98(25): 14637-14642.
Baev D, et al. Killing of Candida albicans by human salivary histatin 5 is modulated, but not determined, by the potassium channel TOK1. Infect Immun. Jun 2003; 71(6): 3251-3260.

Full Name

Histatin 5

Sequence
(one-letter code)

DSHAKRHHGYKRKFHEKHHSHRGY

Sequence
(three-letter code)

{ASP}{SER}{HIS}{ALA}{LYS}{ARG}{HIS}{HIS}{GLY}{TYR}
{LYS}{ARG}{LYS}{PHE}{HIS}{GLU}{LYS}{HIS}{HIS}{SER}
{HIS}{ARG}{GLY}{TYR}

Description

Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro. To elucidate the mechanism of action, the effect of histatin 5 on the viability of Candida albicans cells was studied in relation to its membrane perturbing properties. It was found that both the killing activity and the membrane perturbing activity, studied by the influx of a DNA-specific marker propidium iodide, were inhibited by high salt conditions and by metabolic inhibitors, like sodium azide.

Formula

C₁₃₃H₁₉₅N₅₁O₃₃

M.W.

3036.29

Cas

104339-66-4

Purity

> 95%

Storage

Store at -20°C

Notes

Human parotid histidine-rich protein

* For Non-Clinical Research Use Only *


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