GenScript Catalog Peptide: Myelin Basic Protein (MBP) (1-11), human (RP11629)

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Myelin Basic Protein (MBP) (1-11), human

Cat. No.

Size

Price

Figures

RP11629-1 mg

1 mg

$ 142.50

HPLC:  20060721145623  (PDF)
MS:  20060721145602  (PDF)
MSDS:  20080716022537  (PDF)

References:

Tzakos AG, et al. NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations. Eur. J. Biochem. Aug 2004; 271(16): 3399-3413.
de Rosbo NK, et al. The myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501. J. Immunol. Jul 2004; 173(2):1426-35.

Full Name

Myelin Basic Protein (MBP) (1-11), human

Alias

Myelin Basic Protein (1-11)

Sequence
(one-letter code)

Ac-ASQKRPSQRHG

Sequence
(three-letter code)

Ac-{ALA}{SER}{GLN}{LYS}{ARG}{PRO}{SER}{GLN}{ARG}{HIS}
{GLY}

Description

MBP (1-11) is the major encephalitogenic epitope of the myelin basic protein molecule. The synthetic myelin basic protein MBP (1-11) peptide has been tested in vivo for induction of experimental autoimmune encephalomyelitis (EAE). Myelin basic protein (MBP) is a hydrophilic protein that may help myelin maintain its structure, interacting with the lipids in the myelin membrane by electrostatic and hydrophobic interactions. Myelin basic protein (MBP) is the target of many post-translational modifications: it is N-terminally acetylated, methylated on an arginine residue, phosphorylated by various serine/threonine protein-kinases, and deamidated on some glutamine residues.

Formula

C₅₂H₈₈N₂₂O₁₇

M.W.

1293.4

Purity

> 95%

Storage

Store at -20°C. Keep container tightly closed.

N-Terminal

* For Non-Clinical Research Use Only *

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