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Myelin Basic Protein (MBP) (87-99), human  |
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| Cat. No. |
Size |
Price |
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RP11641-1 mg
| 1 mg | $ 142.50 | HPLC: 20060721145623 (PDF)
MS: 20060721145602 (PDF)
MSDS: 20080716024432 (PDF)
References:
- Hauben E, et al. Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury. J. Neurosci. Sep 2003; 23(25):8808-19.
- Tzakos AG, et al. NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist: structural implications for the MHC II (I-Au)-peptide complex from docking calculations. Eur. J. Biochem. Aug 2004; 271(16):3399-413.
- de Graaf KL, et al. Allelic variations in rat MHC class II binding of myelin basic protein peptides correlate with encephalitogenicity. Int. Immunol. Dec 1999; 11(12):1981-8.
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| Full Name | | Myelin Basic Protein (MBP) (87-99), human |
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| Alias |
Myelin Basic Protein (87-99) |
Sequence
(one-letter code) |
VHFFKNIVTPRTP | Sequence
(three-letter code) | {VAL}{HIS}{PHE}{PHE}{LYS}{ASN}{ILE}{VAL}{THR}{PRO}
{ARG}{THR}{PRO} |
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| Description | The immunodominant myelin basic protein (MBP) peptide, comprising residues 87-99, is a self-antigen in multiple sclerosis (MS). In Lewis rats, this epitope induces experimental allergic encephalomyelitis (EAE), a demyelinating disease of the central nervous system, and is a model of MS. Myelin basic protein (MBP) is a hydrophilic protein that may function to maintain the correct structure of myelin, interacting with the lipids in the myelin membrane by electrostatic and hydrophobic interactions. Myelin basic protein (MBP) is the target of many post-translational modifications: It is N-terminally acetylated, methylated on an arginine residue, phosphorylated by various serine/threonine protein-kinases, and deamidated on some glutamine residues. |
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| Formula | C74H114N20O17 |
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| M.W. | 1555.9 |
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| Purity | > 95% |
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| Storage | Store the peptide at -20°C. Keep container tightly closed. |
| * For Non-Clinical Research Use Only *
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