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Hepatitis C Virus NS3 Protease Inhibitor 1

Cat. No. Size Price Figures
RP11670-1 mg
 		1 mg
$ 171.00
MSDS:  20080919024136  (PDF)


References:
  • Gallinari P. et al. Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. J. Virol. 1998 Aug;72(8):6758-69.
RP11670-5 mg
 		5 mg
$ 513.00
Full Name
Hepatitis C Virus NS3 Protease Inhibitor 1
Sequence
(one-letter code)		 Ac-DEMEEC
Sequence
(three-letter code)		{ASP}{GLU}{MET}{GLU}{GLU}{CYS}
DescriptionHepatitis Virus C NS3 Protease Inhibitor 1 is a potent peptide inhibitor of hepatitis virus C NS3 protease. The hepatitis C virus (HCV) NS3 protease is essential for polyprotein maturation and viral propagation, and it has been proposed as a suitable target for antiviral drug discovery. An N-terminal hexapeptide cleavage product of a dodecapeptide substrate identified as a weak competitive inhibitor of the NS3 protease activity was optimized to a potent and highly specific inhibitor of the enzyme. The effect of this potent NS3 protease inhibitor was evaluated on replication of subgenomic HCV RNA and compared with interferon- (IFN-), which is currently used in the treatment of HCV-infected patients.
FormulaC29H44N6O16S2
M.W.796.82
Purity> 95%
StorageStore the peptide at -20°C.
N-TerminalAC
* For Non-Clinical Research Use Only *
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