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Sauvagine

Cat. No. Size Price Figures
RP11750-0.5 mg
 		0.5 mg
$ 104.00
MSDS:  20080624043357  (PDF)


References:
  • Assil-Kishawi I, Abou-Samra AB. Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor. J. Biol. Chem. Sep 2002; 277(36): 32558-32561.
  • Isfort RJ, et al. Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy. J. Med. Chem. Jan 2005; 48(1): 262-265.
  • Mazur AW, et al. Sauvagine analogs selective for corticotropin releasing factor 2 receptor: effect of substitutions at positions 35 and 39 on CRF2R selectivity. Peptides. May 2005; 26(5): 887-891.
Full Name
Sauvagine
Sequence
(one-letter code)		 PyrGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2
Sequence
(three-letter code)		{pGLU}{GLY}{PRO}{PRO}{ILE}{SER}{ILE}{ASP}{LEU}{SER}
{LEU}{GLU}{LEU}{LEU}{ARG}{LYS}{MET}{ILE}{GLU}{ILE}
{GLU}{LYS}{GLN}{GLU}{LYS}{GLU}{LYS}{GLN}{GLN}{ALA}
{ALA}{ASN}{ASN}{ARG}{LEU}{LEU}{LEU}{ASP}{THR}{ILE}-NH2
C-TerminalNH2
DescriptionSauvagine is a hypotensive, diuretic peptide related to CRF and urotensin 1. It was originally isolated from the skin of the frog Phyllomedusa sauvagei. Sauvagine presents a number of pharmacological actions on diuresis, the cardiovascular system, and the endocrine glands. Sauvagine also potently stimulates the release of ACTH and β-endorphin from the anterior pituitary.
SolubilitySoluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
FormulaC202H346N56O63S
M.W.4599.31
Cas74434-59-6
Purity> 95%
StorageStore at -20°C. Keep container tightly closed.
NotesThe peptide performs a number of pharmacological actions on diuresis, the cardiovascular system, and endocrine glands.
* For Non-Clinical Research Use Only *


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 Peptide Libraries: GenScript has developed a rapid high-throughput parallel peptide synthesis platform, providing custom libraries of unbound peptides of 5-20 mer at very competitive prices.




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