| Cat. No. |
Size |
Price |
Figures |
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RP11750-0.5 mg
| 0.5 mg | $ 104.50 | MSDS: 20080624043357 (PDF)
References:
- Assil-Kishawi I, Abou-Samra AB. Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor. J. Biol. Chem. Sep 2002; 277(36): 32558-32561.
- Isfort RJ, et al. Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy. J. Med. Chem. Jan 2005; 48(1): 262-265.
- Mazur AW, et al. Sauvagine analogs selective for corticotropin releasing factor 2 receptor: effect of substitutions at positions 35 and 39 on CRF2R selectivity. Peptides. May 2005; 26(5): 887-891.
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| Full Name | |
Sequence
(one-letter code) |
PyrGPPISIDLSLELLRKMIEIEKQEKEKQQAANNRLLLDTI-NH2 |
Sequence
(three-letter code) | {pGLU}{GLY}{PRO}{PRO}{ILE}{SER}{ILE}{ASP}{LEU}{SER}
{LEU}{GLU}{LEU}{LEU}{ARG}{LYS}{MET}{ILE}{GLU}{ILE}
{GLU}{LYS}{GLN}{GLU}{LYS}{GLU}{LYS}{GLN}{GLN}{ALA}
{ALA}{ASN}{ASN}{ARG}{LEU}{LEU}{LEU}{ASP}{THR}{ILE}-NH2 |
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| C-Terminal | NH2 |
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| Description | Sauvagine is a hypotensive, diuretic peptide related to CRF and urotensin 1. It was originally isolated from the skin of the frog Phyllomedusa sauvagei. Sauvagine presents a number of pharmacological actions on diuresis, the cardiovascular system, and the endocrine glands. Sauvagine also potently stimulates the release of ACTH and β-endorphin from the anterior pituitary. |
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| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents. |
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| Formula | C202H346N56O63S |
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| M.W. | 4599.31 |
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| Cas | 74434-59-6 |
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| Purity | > 95% |
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| Storage | Store at -20°C. Keep container tightly closed. |
| Notes | The peptide performs a number of pharmacological actions on diuresis, the cardiovascular system, and endocrine glands. |
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