GenScript Catalog Peptide: Vanilloid Receptor Subtype 1 (VR1) (RP11755)

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Vanilloid Receptor Subtype 1 (VR1)

Cat. No.

Size

Price

Figures

RP11755-1 mg

1 mg

$ 99.75

HPLC:  20060721145623  (PDF)
MS:  20060721145602  (PDF)
MSDS:  20080715012932  (PDF)

References:

Stander S, et al. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp. Dermatol. Mar 2004; 13(3): 129-139.
Miyamoto R, et al. Expression and characterization of vanilloid receptor subtype 1 in human dental pulp cell cultures. J. Endod. Sep 2005; 31(9): 652-658.
Fujino K, et al. Attenuation of acid induced oesophagitis in VR-1 deficient mice. Gut. Jan 2006; 55(1): 34-40.

RP11755-5 mg

5 mg

$ 399.00

Full Name

Vanilloid Receptor Subtype 1 (VR1)

Alias

Vanilloid Receptor Subtype1; VR 1; VR1

Sequence
(one-letter code)

CEDAEVFKDSMVPGEK

Sequence
(three-letter code)

{CYS}{GLU}{ASP}{ALA}{GLU}{VAL}{PHE}{LYS}{ASP}{SER}
{MET}{VAL}{PRO}{GLY}{GLU}{LYS}

Description

VR1 is widely distributed in the skin, e.g. in nociception and neurogenic inflammation. VR1 is a capsaicin-receptor homologue with a high threshold for noxious heat. As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.

Formula

C₇₅H₁₁₈N₁₈O₂₈S₂

M.W.

1783.98

Purity

> 95%

Storage

Store at -20°C.

* For Non-Clinical Research Use Only *

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