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TAT

Cat. No. Size Price Figures
RP12784-0.5 mg
 		0.5 mg
$ 43.00
MS:  20060721145603  (PDF)
HPLC:  20060721145623  (PDF)
MSDS:  20080331023958  (PDF)
PROTOCOL:  20100407015038  (PDF)

STRUCTURE:
TAT structure
Zoom

References:
  • Hoque M, et al. Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation. J. Biol. Chem. Apr 2005; 280(14): 13648-13657.
  • Mondal D, et al. The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp. Biol. Med.(Maywood). Oct 2005; 230(9): 631-644.
  • Kittiworakarn J, et al. HIV-1 Tat raises an adjuvant-free humoral immune response controlled by its core region and its ability to form cysteine-mediated oligomers. J. Biol. Chem. Feb 2006; 281(6): 3105-3115.
RP12784-5 mg
 		5 mg
$ 285.00
Full Name
TAT
Sequence
(one-letter code)		 YGRKKRRQRRR-NH2
Sequence
(three-letter code)		{TYR}{GLY}{ARG}{LYS}{LYS}{ARG}{ARG}{GLN}{ARG}{ARG}
{ARG}-NH2
C-TerminalNH2
DescriptionTaT is a transcriptional transactivator protein that binds to a regulatory element in the HIV-1 long terminal repeat. By recruiting P-TEFb to TAR, TaT promotes transcription of viral mRNA. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. TaT has similar immunosuppressive effects as transforming growth factor-beta (TGF beta) and both inhibit lymphocyte proliferation.
FormulaC64H119N33O13
M.W.1558.85
Purity> 95%
StorageStore at -20°C. Keep tightly closed. Store in a cool dry place.
* For Non-Clinical Research Use Only *
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