Hoque M, et al. Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation. J. Biol. Chem. Apr 2005; 280(14): 13648-13657.
Mondal D, et al. The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp. Biol. Med.(Maywood). Oct 2005; 230(9): 631-644.
Kittiworakarn J, et al. HIV-1 Tat raises an adjuvant-free humoral immune response controlled by its core region and its ability to form cysteine-mediated oligomers. J. Biol. Chem. Feb 2006; 281(6): 3105-3115.
TaT is a transcriptional transactivator protein that binds to a regulatory element in the HIV-1 long terminal repeat. By recruiting P-TEFb to TAR, TaT promotes transcription of viral mRNA. This arginine-rich TAT peptide penetrates plasma membrane directly, but not through endocytosis. TaT has similar immunosuppressive effects as transforming growth factor-beta (TGF beta) and both inhibit lymphocyte proliferation.
Formula
C64H119N33O13
M.W.
1558.85
Purity
> 95%
Storage
Store at -20°C. Keep tightly closed. Store in a cool dry place.
* For Non-Clinical Research Use Only *
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