Lundquist JT 4th, et al. Synthesis of neurotensin(9-13) analogues exhibiting enhanced human neurotensin receptor binding affinities. Bioorg. Med. Chem. Lett. Mar 2000; 10(5): 453-455.
Lundquist JT 4th, Dix TA. Preparation and receptor binding affinities of cyclic C-terminal neurotensin (8-13) and (9-13) analogues. Bioorg. Med. Chem. Lett. Sep 1999; 9(17): 2579-2582.
Full Name
Neurotensin (9-13)
Sequence (one-letter code)
RPYIL
Sequence (three-letter code)
{ARG}{PRO}{TYR}{ILE}{LEU}
Description
Neurotensin(9-13) was the shortest partial sequence that fully inhibited tritiated neurotensin degradation; shortening the C-terminal part of the neurotensin molecule led to inactive fragments. Cyclic analogues of neurotensin (NT) C-terminal fragments neurotensin(8-13) and neurotensin(9-13) were produced via intramolecular nucleophilic substitution of the Tyr(11) phenoxide anion on a 6-bromohexanoyl side chain substituted at position 8 or 9 and tested for neurotensin receptor binding affinity.
Formula
C32H52N8O7
M.W.
660.41
Purity
> 95%
Storage
Store at -20°C. Keep tightly closed. Store in a cool dry place.
* For Non-Clinical Research Use Only *
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